NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease

Roberto F. Machado, Mariana Hildesheim, Laurel Mendelsohn, Alan T. Remaley, Gregory J. Kato, Mark T. Gladwin

Research output: Contribution to journalArticle

Abstract

Epidemiological studies support a hypothesis that pulmonary hypertension (PH) is a common complication of sickle cell disease (SCD) that is associated with a high risk of death and evolves as a complication of haemolytic anaemia. This fundamental hypothesis has been recently challenged and remains controversial. In order to further test this hypothesis in a large and independent cohort of SCD patients we obtained plasma samples from the Cooperative Study of Sickle Cell Disease (CSSCD) for analysis of a biomarker, N-terminal-pro brain natriuretic peptide (NT-proBNP), which is elevated in the setting of pulmonary arterial and venous hypertension. A NT-pro-BNP value previously identified to predict PH in adults with SCD was used to determine the association between the risk of mortality in 758 CSSCD participants (428 children and 330 adults). An abnormally high NT-proBNP level ≥160ng/l was present in 27·6% of adult SCD patients. High levels were associated with markers of haemolytic anaemia, such as low haemoglobin level (P

Original languageEnglish (US)
Pages (from-to)512-520
Number of pages9
JournalBritish Journal of Haematology
Volume154
Issue number4
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Brain Natriuretic Peptide
Sickle Cell Anemia
Hemolytic Anemia
Pulmonary Hypertension
Epidemiologic Studies
Biomarkers
Hypertension
Lung
Mortality

Keywords

  • Biomarkers
  • Brain natriuretic peptide
  • Pulmonary hypertension
  • Sickle cell disease
  • Survival

ASJC Scopus subject areas

  • Hematology

Cite this

NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease. / Machado, Roberto F.; Hildesheim, Mariana; Mendelsohn, Laurel; Remaley, Alan T.; Kato, Gregory J.; Gladwin, Mark T.

In: British Journal of Haematology, Vol. 154, No. 4, 08.2011, p. 512-520.

Research output: Contribution to journalArticle

Machado, Roberto F. ; Hildesheim, Mariana ; Mendelsohn, Laurel ; Remaley, Alan T. ; Kato, Gregory J. ; Gladwin, Mark T. / NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease. In: British Journal of Haematology. 2011 ; Vol. 154, No. 4. pp. 512-520.
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