(N‐[11C]‐Methyl)doxepin: Synthesis of a radiotracer for studying the histamine H‐1 receptor

Hayden T. Ravert, Robert F. Dannals, Alan A. Wilson, Henry N. Wagner

Research output: Contribution to journalArticle

Abstract

Doxepin (3‐dibenz [b,e] oxepin ‐ 11(6H) ‐ ylidene ‐ N,N ‐ dimethyl ‐ 1 ‐ propanamine), a potent H1 histamine antagonist, was labeled with 11C‐iodomethane by N‐alkylation of normethyldoxepin. The synthesis, purification, and formulation were performed in approximately 20 minutes with an average specific activity of 1630 mCi/μmol (EOS).

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume31
Issue number5
DOIs
StatePublished - May 1992

Keywords

  • Doxepin
  • carbon‐11
  • histamine
  • positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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