TY - JOUR
T1 - NSAID-induced polyp regression in familial adenomatous polyposis patients
AU - Giardiello, F. M.
N1 - Funding Information:
This work was supported by Grant No. NIH UO1 CA53801-03A1.
PY - 1996
Y1 - 1996
N2 - NSAIDs inhibit prostaglandin synthesis. In 1983, Waddell et al first reported that sulindac, a NSAID (Clinoril), caused regression of rectal adenomatous polyps in several patients with familial adenomatous polyposis, an inherited form of colorectal cancer. Subsequently, NSAIDs have been used as chemopreventive agents in animal carcinogenesis models and adenoma regression has been confirmed in human trials with sulindac. This article summarizes these developments and describes possible mechanisms of colorectal neoplasia chemoprevention.
AB - NSAIDs inhibit prostaglandin synthesis. In 1983, Waddell et al first reported that sulindac, a NSAID (Clinoril), caused regression of rectal adenomatous polyps in several patients with familial adenomatous polyposis, an inherited form of colorectal cancer. Subsequently, NSAIDs have been used as chemopreventive agents in animal carcinogenesis models and adenoma regression has been confirmed in human trials with sulindac. This article summarizes these developments and describes possible mechanisms of colorectal neoplasia chemoprevention.
UR - http://www.scopus.com/inward/record.url?scp=0029896486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029896486&partnerID=8YFLogxK
U2 - 10.1016/S0889-8553(05)70251-X
DO - 10.1016/S0889-8553(05)70251-X
M3 - Article
C2 - 9229577
AN - SCOPUS:0029896486
VL - 25
SP - 349
EP - 361
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
SN - 0889-8553
IS - 2
ER -