NSAID-induced polyp regression in familial adenomatous polyposis patients

F. M. Giardiello

doi:10.1016/S0889-8553(05)70251-X

NSAID-induced polyp regression in familial adenomatous polyposis patients

F. M. Giardiello

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

NSAIDs inhibit prostaglandin synthesis. In 1983, Waddell et al first reported that sulindac, a NSAID (Clinoril), caused regression of rectal adenomatous polyps in several patients with familial adenomatous polyposis, an inherited form of colorectal cancer. Subsequently, NSAIDs have been used as chemopreventive agents in animal carcinogenesis models and adenoma regression has been confirmed in human trials with sulindac. This article summarizes these developments and describes possible mechanisms of colorectal neoplasia chemoprevention.

Original language	English (US)
Pages (from-to)	349-361
Number of pages	13
Journal	Gastroenterology Clinics of North America
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/S0889-8553(05)70251-X
State	Published - Jan 1 1996

ASJC Scopus subject areas

Gastroenterology

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abstract = "NSAIDs inhibit prostaglandin synthesis. In 1983, Waddell et al first reported that sulindac, a NSAID (Clinoril), caused regression of rectal adenomatous polyps in several patients with familial adenomatous polyposis, an inherited form of colorectal cancer. Subsequently, NSAIDs have been used as chemopreventive agents in animal carcinogenesis models and adenoma regression has been confirmed in human trials with sulindac. This article summarizes these developments and describes possible mechanisms of colorectal neoplasia chemoprevention.",

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