Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress

Carlton A W Evans, Michael S. Harbuz, Thor Ostenfeld, Alan Norrish, Jenefer M. Blackwell

Research output: Contribution to journalArticle

Abstract

The gene Nramp1 encoding the natural resistance-associated macrophage protein (Nramp1) influences susceptibility to intracellular infections and autoimmune diseases, and the humoral response to stress. Nramp1 functions as a proton/divalent cation antiporter in the membranes of late endosomes/lysosomes, regulating cytoplasmic iron levels in macrophages. The Drosophila homologue of Nramp1 is expressed in sensory neurons and macrophages, and influences taste behaviour directly through divalent cation transport. Here we demonstrate that murine Nramp1 is also expressed on neurons as well as microglial cells in the brain and influences the behavioural response to stress, hypothalamus-pituitary-adrenal (HPA) axis activation and mortality following Tomplasma gondii infection in control and prestressed mice. We hypothesise that, although differences in HPA activation translate into differences in adrenal enlargement and basal circulating corticosterone levels, the primary influence of Nramp1 is at the level of the neuronal response to stress. These results provide new insight into the possible roles of divalent cation transporters of the Nramp gene family in regulating metal ion homeostasis in the brain and its pathological implications.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalNeurogenetics
Volume3
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Divalent Cations
Neurons
Hypothalamus
Macrophages
Antiporters
Endosomes
Brain
Sensory Receptor Cells
Infection Control
Corticosterone
Lysosomes
Genes
Autoimmune Diseases
Drosophila
Protons
Homeostasis
Iron
Metals
Ions
Membranes

Keywords

  • Corticosterone
  • Corticotrophin releasing hormone
  • Divalent cation transporter
  • Hypothalamus-pituitary-adrenal axis
  • Toxoplasma

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)

Cite this

Evans, C. A. W., Harbuz, M. S., Ostenfeld, T., Norrish, A., & Blackwell, J. M. (2001). Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress. Neurogenetics, 3(2), 69-78. https://doi.org/10.1007/s100480100105

Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress. / Evans, Carlton A W; Harbuz, Michael S.; Ostenfeld, Thor; Norrish, Alan; Blackwell, Jenefer M.

In: Neurogenetics, Vol. 3, No. 2, 2001, p. 69-78.

Research output: Contribution to journalArticle

Evans, CAW, Harbuz, MS, Ostenfeld, T, Norrish, A & Blackwell, JM 2001, 'Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress', Neurogenetics, vol. 3, no. 2, pp. 69-78. https://doi.org/10.1007/s100480100105
Evans, Carlton A W ; Harbuz, Michael S. ; Ostenfeld, Thor ; Norrish, Alan ; Blackwell, Jenefer M. / Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress. In: Neurogenetics. 2001 ; Vol. 3, No. 2. pp. 69-78.
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