NRAMP1 gene polymorphisms in patients with rheumatoid arthritis

D. P. Singal, J. Li, Yaohui Zhu, G. Zhang

Research output: Contribution to journalArticle

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease associated with HLA-DR genes that share amino acid sequence motif QKRAA/QRRAA from position 70 to 74 in the third hypervariable region of DR1 molecule. The contribution of HLA in RA is however about 37, suggesting a role for ether genes. One such candidate is the gene that encodes natural resistance-associated macrophage protein (NRAMP1), which plays a crucial role in inflammation and tissue destruction. In the present study, we examined the role of NRAMP1 gene polymorphisms in susceptibility to RA. The results show that variation at position 543 in exon 15, which involves substitution of negatively charged aspartic acid (D) by uncharged asparagine (N), and the deletion of TGTG in the 3' UTR may confer protection from development of RA.

Original languageEnglish (US)
Pages (from-to)44-47
Number of pages4
JournalTissue Antigens
Volume55
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Rheumatoid Arthritis
tyrosyl-glutamyl-tyrosyl-glutamic acid
Genes
D-Aspartic Acid
Amino Acid Motifs
Joint Diseases
Asparagine
3' Untranslated Regions
HLA-DR Antigens
Ether
Amino Acid Sequence
Exons
Inflammation

Keywords

  • NRAMP1
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

NRAMP1 gene polymorphisms in patients with rheumatoid arthritis. / Singal, D. P.; Li, J.; Zhu, Yaohui; Zhang, G.

In: Tissue Antigens, Vol. 55, No. 1, 2000, p. 44-47.

Research output: Contribution to journalArticle

Singal, D. P. ; Li, J. ; Zhu, Yaohui ; Zhang, G. / NRAMP1 gene polymorphisms in patients with rheumatoid arthritis. In: Tissue Antigens. 2000 ; Vol. 55, No. 1. pp. 44-47.
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