NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: A comparative analysis of 2562 patients with acute myeloid leukemia

Brunangelo Falini; Cristina Mecucci; Giuseppe Saglio; Francesco Lo Coco; Daniela Diverio; Patrick Brown; Fabrizio Pane; Marco Mancini; Maria Paola Martelli; Stefano Pileri; Torsten Haferlach; Claudia Haferlach; Susanne Schnittger

doi:10.3324/haematol.12153

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: A comparative analysis of 2562 patients with acute myeloid leukemia

Brunangelo Falini, Cristina Mecucci, Giuseppe Saglio, Francesco Lo Coco, Daniela Diverio, Patrick Brown, Fabrizio Pane, Marco Mancini, Maria Paola Martelli, Stefano Pileri, Torsten Haferlach, Claudia Haferlach, Susanne Schnittger

School of Medicine

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Abstract

Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc⁺ acute myeloid leukemia) represents onethird of adult AML (50-60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities. Taken together, these findings make NPMc+ acute myeloid leukemia a good candidate for inclusion in the upcoming World Health Organization classification.

Original language	English (US)
Pages (from-to)	439-442
Number of pages	4
Journal	Haematologica
Volume	93
Issue number	3
DOIs	https://doi.org/10.3324/haematol.12153
State	Published - Mar 2008

Keywords

Acute myeloid leukemia
Antibodies
Immunohistochemistry
Mutations
NPM
Nucleophosmin

ASJC Scopus subject areas

Hematology

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10.3324/haematol.12153

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Falini, B., Mecucci, C., Saglio, G., Lo Coco, F., Diverio, D., Brown, P., Pane, F., Mancini, M., Martelli, M. P., Pileri, S., Haferlach, T., Haferlach, C., & Schnittger, S. (2008). NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: A comparative analysis of 2562 patients with acute myeloid leukemia. Haematologica, 93(3), 439-442. https://doi.org/10.3324/haematol.12153

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities : A comparative analysis of 2562 patients with acute myeloid leukemia. / Falini, Brunangelo; Mecucci, Cristina; Saglio, Giuseppe; Lo Coco, Francesco; Diverio, Daniela; Brown, Patrick; Pane, Fabrizio; Mancini, Marco; Martelli, Maria Paola; Pileri, Stefano; Haferlach, Torsten; Haferlach, Claudia; Schnittger, Susanne.

In: Haematologica, Vol. 93, No. 3, 03.2008, p. 439-442.

Research output: Contribution to journal › Article › peer-review

Falini, B, Mecucci, C, Saglio, G, Lo Coco, F, Diverio, D, Brown, P, Pane, F, Mancini, M, Martelli, MP, Pileri, S, Haferlach, T, Haferlach, C & Schnittger, S 2008, 'NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: A comparative analysis of 2562 patients with acute myeloid leukemia', Haematologica, vol. 93, no. 3, pp. 439-442. https://doi.org/10.3324/haematol.12153

Falini, Brunangelo ; Mecucci, Cristina ; Saglio, Giuseppe ; Lo Coco, Francesco ; Diverio, Daniela ; Brown, Patrick ; Pane, Fabrizio ; Mancini, Marco ; Martelli, Maria Paola ; Pileri, Stefano ; Haferlach, Torsten ; Haferlach, Claudia ; Schnittger, Susanne. / NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities : A comparative analysis of 2562 patients with acute myeloid leukemia. In: Haematologica. 2008 ; Vol. 93, No. 3. pp. 439-442.

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abstract = "Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ acute myeloid leukemia) represents onethird of adult AML (50-60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities. Taken together, these findings make NPMc+ acute myeloid leukemia a good candidate for inclusion in the upcoming World Health Organization classification.",

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AU - Lo Coco, Francesco

AU - Diverio, Daniela

AU - Brown, Patrick

AU - Pane, Fabrizio

AU - Mancini, Marco

AU - Martelli, Maria Paola

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AB - Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ acute myeloid leukemia) represents onethird of adult AML (50-60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities. Taken together, these findings make NPMc+ acute myeloid leukemia a good candidate for inclusion in the upcoming World Health Organization classification.

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NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: A comparative analysis of 2562 patients with acute myeloid leukemia

Abstract

Keywords

ASJC Scopus subject areas

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