Novel variation at chr11p13 associated with cystic fibrosis lung disease severity

Hong Dang, Paul J. Gallins, Rhonda G. Pace, Xue Liang Guo, Jaclyn R. Stonebraker, Harriet Corvol, Garry R. Cutting, Mitchell L. Drumm, Lisa J. Strug, Michael R. Knowles, Wanda K. O'Neal

Research output: Contribution to journalArticlepeer-review

Abstract

Published genome-wide association studies (GWASs) identified an intergenic region with regulatory features on chr11p13 associated with cystic fibrosis (CF) lung disease severity. Targeted resequencing in n=377, followed by imputation to n=6,365 CF subjects, was used to identify unrecognized genetic variants (including indels and microsatellite repeats) associated with phenotype. Highly significant associations were in strong linkage disequilibrium and were seen only in Phe508del homozygous CF subjects, indicating a CFTR genotype-specific mechanism.

Original languageEnglish (US)
Article number201620
JournalHuman Genome Variation
Volume3
DOIs
StatePublished - Jul 7 2016

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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