Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

Chemical Compounds

• Reduced Cytochrome P450 100%
• Itraconazole 74%
• Antiangiogenic 69%
• Cytochrome P450 53%
• 1,2,4-triazole 39%
• Angiogenesis Inhibitor 28%
• Tetrazole 20%
• Azole 20%
• Drug 17%
• Antitumor 15%
• Metabolic 13%

Medicine & Life Sciences

• 1H-tetrazole 84%
• Angiogenesis Inhibitors 60%
• Itraconazole 60%
• 1,2,4-triazole 58%
• Cytochrome P-450 CYP3A 57%
• Azoles 21%
• Human Umbilical Vein Endothelial Cells 18%
• Sirolimus 17%
• Pharmaceutical Preparations 13%
• Clinical Studies 11%
• Cell Proliferation 11%
• Phenotype 10%
• Enzymes 9%
• Neoplasms 5%