Novel technique to control hypersecretion from a transplanted autologous submandibular salivary gland for keratoconjunctivitis sicca

Igal Leibovitch, Erika Hoyama, Vanessa Limawararut, John Crompton, Dinesh Selva

Research output: Contribution to journalArticle

Abstract

PURPOSE: To present a novel technique to control hypersecretion from a transplanted autologous submandibular gland (SMG) in a patient with keratoconjunctivitis sicca. METHODS: A 65-year-old man presented with corneal epithelial edema and suspicious ocular surface dysplasia secondary to hypersecretion from a transplanted autologous SMG. The location and function of the gland were evaluated perioperatively using technetium-99m-pertechnetate scintigraphy. The course of the duct was marked with a radiation probe, surgically exposed, and partially ligated with titanium clips. RESULTS: Marked reduction in salivary flow and resolution of corneal edema and ocular surface changes were noted. Conjunctival biopsy showed no evidence of malignancy. Symptoms were stable during a 1-year follow-up period. CONCLUSION: Partial ligation of the transplanted SMG duct may be a simple and reversible technique to control hypersecreting glands with secondary corneal edema and ocular surface changes.

Original languageEnglish (US)
Pages (from-to)1251-1253
Number of pages3
JournalCornea
Volume25
Issue number10
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Keratoconjunctivitis Sicca
Corneal Edema
Submandibular Gland
Salivary Glands
Sodium Pertechnetate Tc 99m
Technetium
Titanium
Surgical Instruments
Radionuclide Imaging
Ligation
Radiation
Biopsy
Neoplasms

Keywords

  • Autologous submandibular salivary gland
  • Hypersecretion
  • Keratoconjunctivitis sicca

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Novel technique to control hypersecretion from a transplanted autologous submandibular salivary gland for keratoconjunctivitis sicca. / Leibovitch, Igal; Hoyama, Erika; Limawararut, Vanessa; Crompton, John; Selva, Dinesh.

In: Cornea, Vol. 25, No. 10, 12.2006, p. 1251-1253.

Research output: Contribution to journalArticle

Leibovitch, Igal ; Hoyama, Erika ; Limawararut, Vanessa ; Crompton, John ; Selva, Dinesh. / Novel technique to control hypersecretion from a transplanted autologous submandibular salivary gland for keratoconjunctivitis sicca. In: Cornea. 2006 ; Vol. 25, No. 10. pp. 1251-1253.
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AU - Crompton, John

AU - Selva, Dinesh

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AB - PURPOSE: To present a novel technique to control hypersecretion from a transplanted autologous submandibular gland (SMG) in a patient with keratoconjunctivitis sicca. METHODS: A 65-year-old man presented with corneal epithelial edema and suspicious ocular surface dysplasia secondary to hypersecretion from a transplanted autologous SMG. The location and function of the gland were evaluated perioperatively using technetium-99m-pertechnetate scintigraphy. The course of the duct was marked with a radiation probe, surgically exposed, and partially ligated with titanium clips. RESULTS: Marked reduction in salivary flow and resolution of corneal edema and ocular surface changes were noted. Conjunctival biopsy showed no evidence of malignancy. Symptoms were stable during a 1-year follow-up period. CONCLUSION: Partial ligation of the transplanted SMG duct may be a simple and reversible technique to control hypersecreting glands with secondary corneal edema and ocular surface changes.

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