Novel structured reporting systems for theranostic radiotracers

Rudolf A. Werner, Ralph A. Bundschuh, Lena Bundschuh, Stefano Fanti, Mehrbod S. Javadi, Takahiro Higuchi, Alexander Weich, Kenneth J. Pienta, Andreas K. Buck, Martin G. Pomper, Michael A. Gorin, Ken Herrmann, Constantin Lapa, Steven P. Rowe

Research output: Contribution to journalArticle

Abstract

Standardized reporting is more and more routinely implemented in clinical practice, and such structured reports have a major impact on a large variety of medical fields, such as laboratory medicine, pathology, and, recently, radiology. Notably, the field of nuclear medicine is constantly evolving as novel radiotracers for numerous clinical applications are developed. Thus, framework systems for standardized reporting in this field may increase clinical acceptance of new radiotracers, allow for inter- and intracenter comparisons for quality assurance, and be used in global multicenter studies to ensure comparable results and enable efficient data abstraction. In the last couple of years, several standardized framework systems for PET radiotracers with potential theranostic applications have been proposed. These include systems for prostate-specific membrane antigen–targeted PET agents to diagnose and treat prostate cancer, and systems for somatostatin receptor–targeted PET agents to diagnose and treat neuroendocrine neoplasia. In the present review, the framework systems for these 2 types of cancer will be briefly introduced, followed by an overview of their advantages and limitations. In addition, potential applications will be defined, approaches to validate such concepts will be proposed, and future perspectives will be discussed.

Original languageEnglish (US)
Pages (from-to)577-584
Number of pages8
JournalJournal of Nuclear Medicine
Volume60
Issue number5
DOIs
StatePublished - May 1 2019

Keywords

  • Ga-DOTANOC
  • Ga-DOTATATE
  • Ga-DOTATOC
  • Neuroendocrine neoplasia
  • Prostate cancer
  • Somatostatin receptor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Werner, R. A., Bundschuh, R. A., Bundschuh, L., Fanti, S., Javadi, M. S., Higuchi, T., Weich, A., Pienta, K. J., Buck, A. K., Pomper, M. G., Gorin, M. A., Herrmann, K., Lapa, C., & Rowe, S. P. (2019). Novel structured reporting systems for theranostic radiotracers. Journal of Nuclear Medicine, 60(5), 577-584. https://doi.org/10.2967/jnumed.118.223537