Novel, single-beat approach for determining both end-systolic pressure-dimension relationship and preload recruitable stroke work

Ryo Inuzuka, David A Kass, Hideaki Senzaki

Research output: Contribution to journalArticle

Abstract

Objective: The end-systolic pressure-dimension relationship (ESPDR) and the preload recruitable stroke work (PRSW) relationship are load-insensitive measures of contractility, but their clinical application has been limited by the need to record multiple beats over a wide volume range. In this study, we therefore sought to validate a new method to concomitantly determine the ESPDR and the PRSW relationship from a single beat. Methods: Pressure-dimension loops were recorded in 14 conscious dogs under various haemodynamic and pathological conditions. Multiple-beat PRSW relationship was determined for its slope (Mw) and for a dimension-axis intercept (Dw). The ESPDR represented by the formula Pes(Des) = A ln (Des=D0)=(Des=D0)3g, was estimated from a steady-state, single-beat late-systolic pressure- dimension relationship. The single-beat Mw was determined as an end-systolic pressure when the endsystolic dimension was equal to Dw. Results: A strong correlation was observed between multiple-beat and single-beat ESPDRs (zero-stress dimension; r=0.98, p

Original languageEnglish (US)
Article numbere000451
JournalOpen Heart
Volume3
Issue number1
DOIs
StatePublished - Jun 1 2016

Fingerprint

Stroke
Blood Pressure
Workload
Hemodynamics
Dogs
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Novel, single-beat approach for determining both end-systolic pressure-dimension relationship and preload recruitable stroke work. / Inuzuka, Ryo; Kass, David A; Senzaki, Hideaki.

In: Open Heart, Vol. 3, No. 1, e000451, 01.06.2016.

Research output: Contribution to journalArticle

@article{e10ea8e041fe47b6b6a3866eb825fbf0,
title = "Novel, single-beat approach for determining both end-systolic pressure-dimension relationship and preload recruitable stroke work",
abstract = "Objective: The end-systolic pressure-dimension relationship (ESPDR) and the preload recruitable stroke work (PRSW) relationship are load-insensitive measures of contractility, but their clinical application has been limited by the need to record multiple beats over a wide volume range. In this study, we therefore sought to validate a new method to concomitantly determine the ESPDR and the PRSW relationship from a single beat. Methods: Pressure-dimension loops were recorded in 14 conscious dogs under various haemodynamic and pathological conditions. Multiple-beat PRSW relationship was determined for its slope (Mw) and for a dimension-axis intercept (Dw). The ESPDR represented by the formula Pes(Des) = A ln (Des=D0)=(Des=D0)3g, was estimated from a steady-state, single-beat late-systolic pressure- dimension relationship. The single-beat Mw was determined as an end-systolic pressure when the endsystolic dimension was equal to Dw. Results: A strong correlation was observed between multiple-beat and single-beat ESPDRs (zero-stress dimension; r=0.98, p",
author = "Ryo Inuzuka and Kass, {David A} and Hideaki Senzaki",
year = "2016",
month = "6",
day = "1",
doi = "10.1136/openhrt-2016-000451 1",
language = "English (US)",
volume = "3",
journal = "Open Heart",
issn = "2053-3624",
publisher = "BMJ Publishing Group",
number = "1",

}

TY - JOUR

T1 - Novel, single-beat approach for determining both end-systolic pressure-dimension relationship and preload recruitable stroke work

AU - Inuzuka, Ryo

AU - Kass, David A

AU - Senzaki, Hideaki

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objective: The end-systolic pressure-dimension relationship (ESPDR) and the preload recruitable stroke work (PRSW) relationship are load-insensitive measures of contractility, but their clinical application has been limited by the need to record multiple beats over a wide volume range. In this study, we therefore sought to validate a new method to concomitantly determine the ESPDR and the PRSW relationship from a single beat. Methods: Pressure-dimension loops were recorded in 14 conscious dogs under various haemodynamic and pathological conditions. Multiple-beat PRSW relationship was determined for its slope (Mw) and for a dimension-axis intercept (Dw). The ESPDR represented by the formula Pes(Des) = A ln (Des=D0)=(Des=D0)3g, was estimated from a steady-state, single-beat late-systolic pressure- dimension relationship. The single-beat Mw was determined as an end-systolic pressure when the endsystolic dimension was equal to Dw. Results: A strong correlation was observed between multiple-beat and single-beat ESPDRs (zero-stress dimension; r=0.98, p

AB - Objective: The end-systolic pressure-dimension relationship (ESPDR) and the preload recruitable stroke work (PRSW) relationship are load-insensitive measures of contractility, but their clinical application has been limited by the need to record multiple beats over a wide volume range. In this study, we therefore sought to validate a new method to concomitantly determine the ESPDR and the PRSW relationship from a single beat. Methods: Pressure-dimension loops were recorded in 14 conscious dogs under various haemodynamic and pathological conditions. Multiple-beat PRSW relationship was determined for its slope (Mw) and for a dimension-axis intercept (Dw). The ESPDR represented by the formula Pes(Des) = A ln (Des=D0)=(Des=D0)3g, was estimated from a steady-state, single-beat late-systolic pressure- dimension relationship. The single-beat Mw was determined as an end-systolic pressure when the endsystolic dimension was equal to Dw. Results: A strong correlation was observed between multiple-beat and single-beat ESPDRs (zero-stress dimension; r=0.98, p

UR - http://www.scopus.com/inward/record.url?scp=84975261036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975261036&partnerID=8YFLogxK

U2 - 10.1136/openhrt-2016-000451 1

DO - 10.1136/openhrt-2016-000451 1

M3 - Article

AN - SCOPUS:84975261036

VL - 3

JO - Open Heart

JF - Open Heart

SN - 2053-3624

IS - 1

M1 - e000451

ER -