Novel roles for the NF-κB signaling pathway in regulating neuronal function

Matt C. Boersma, Mollie K Meffert

Research output: Contribution to journalArticle

Abstract

Two new reports offer exciting evidence of novel roles for components of the nuclear factor κB (NF-κB) pathway in the nervous system. Transcriptional activation by NF-κB and chromatin remodeling by inhibitor of κB (IκB) kinase complex (IKK) have been linked to recall and reconsolidation of conditioned fear memories in the mammalian central nervous system. In the Drosophila neuromuscular junction, a member of the NF-κB family has been reported to regulate glutamate receptor clustering. Both reports could have important implications for the function of the NF-κB signaling pathway in neuronal plasticity.

Original languageEnglish (US)
Article number16pe7
JournalScience Signaling
Volume1
Issue number6
DOIs
StatePublished - Feb 12 2008

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Neuronal Plasticity
Chromatin Assembly and Disassembly
Neuromuscular Junction
Glutamate Receptors
Neurology
Nervous System
Transcriptional Activation
Drosophila
Fear
Cluster Analysis
Phosphotransferases
Central Nervous System
Chromatin
Plasticity
Chemical activation
Data storage equipment

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Novel roles for the NF-κB signaling pathway in regulating neuronal function. / Boersma, Matt C.; Meffert, Mollie K.

In: Science Signaling, Vol. 1, No. 6, 16pe7, 12.02.2008.

Research output: Contribution to journalArticle

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