Novel Radiographic Assessment of the Cribriform Plate

Kimia G. Ganjaei; Zachary M. Soler; Elliott D. Mappus; Robert J. Taylor; Mitchell L. Worley; Jennifer K. Mulligan; Jose L. Mattos; Nicholas R. Rowan; Guilherme J.M. Garcia; Judy R. Dubno; Mark A. Eckert; Lois J. Matthews; Rodney J. Schlosser

doi:10.1177/1945892418768159

Novel Radiographic Assessment of the Cribriform Plate

Kimia G. Ganjaei, Zachary M. Soler, Elliott D. Mappus, Robert J. Taylor, Mitchell L. Worley, Jennifer K. Mulligan, Jose L. Mattos, Nicholas R. Rowan, Guilherme J.M. Garcia, Judy R. Dubno, Mark A. Eckert, Lois J. Matthews, Rodney J. Schlosser

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: The cribriform plate (CP) is a common site of spontaneous cerebrospinal fluid (SCSF) leaks. Radiographic assessment of the anterior and lateral skull base has shown thinner bone in patients with SCSFs; however, prior assessment of the CP has required postmortem cadaver dissection. Objective: To develop novel radiographic techniques to assess the anatomy of the CP. Methods: Computed tomography (CT) scans were performed on cadaveric specimens. Bone density and anatomy of a predefined volume of interest of the posterior CP were assessed by two independent reviewers. CT assessment of olfactory foramina was also performed and validated using anatomic dissection of cadaver specimens. Results: Interclass correlation coefficients (ICCs) for measuring the same volume of each CP was 0.96, confirming reproducible anatomic localization. Cadaver CPs had a mean Hounsfield units of 263, indicating a mix of bone and soft tissue, and ICC was 0.98, confirming reproducible radiographic measurements. Optimal CT estimates of bone composition of CPs averaged 85% (range 76% to 96%) compared to actual anatomic dissection which averaged 84% bone (range 74% to 91%, r =.690, P =.026). Conclusion: Our novel, noninvasive CT method for assessing CP anatomy is reproducible and correlates with anatomic dissection assessing bone composition. The clinical implications of anatomic changes in the CP are an area for further study.

Original language	English (US)
Pages (from-to)	175-180
Number of pages	6
Journal	American Journal of Rhinology and Allergy
Volume	32
Issue number	3
DOIs	https://doi.org/10.1177/1945892418768159
State	Published - May 2018
Externally published	Yes

Keywords

anatomy
bone density
cerebrospinal fluid leak
computed tomography
craniofacial
cribriform plate
encephalocele
ethmoid bone
olfactory foramina
skull base

ASJC Scopus subject areas

Immunology and Allergy
Otorhinolaryngology

Access to Document

10.1177/1945892418768159

Cite this

@article{77feba6cf947476f8f22d4ab818c33e6,

title = "Novel Radiographic Assessment of the Cribriform Plate",

abstract = "Background: The cribriform plate (CP) is a common site of spontaneous cerebrospinal fluid (SCSF) leaks. Radiographic assessment of the anterior and lateral skull base has shown thinner bone in patients with SCSFs; however, prior assessment of the CP has required postmortem cadaver dissection. Objective: To develop novel radiographic techniques to assess the anatomy of the CP. Methods: Computed tomography (CT) scans were performed on cadaveric specimens. Bone density and anatomy of a predefined volume of interest of the posterior CP were assessed by two independent reviewers. CT assessment of olfactory foramina was also performed and validated using anatomic dissection of cadaver specimens. Results: Interclass correlation coefficients (ICCs) for measuring the same volume of each CP was 0.96, confirming reproducible anatomic localization. Cadaver CPs had a mean Hounsfield units of 263, indicating a mix of bone and soft tissue, and ICC was 0.98, confirming reproducible radiographic measurements. Optimal CT estimates of bone composition of CPs averaged 85% (range 76% to 96%) compared to actual anatomic dissection which averaged 84% bone (range 74% to 91%, r =.690, P =.026). Conclusion: Our novel, noninvasive CT method for assessing CP anatomy is reproducible and correlates with anatomic dissection assessing bone composition. The clinical implications of anatomic changes in the CP are an area for further study.",

keywords = "anatomy, bone density, cerebrospinal fluid leak, computed tomography, craniofacial, cribriform plate, encephalocele, ethmoid bone, olfactory foramina, skull base",

author = "Ganjaei, {Kimia G.} and Soler, {Zachary M.} and Mappus, {Elliott D.} and Taylor, {Robert J.} and Worley, {Mitchell L.} and Mulligan, {Jennifer K.} and Mattos, {Jose L.} and Rowan, {Nicholas R.} and Garcia, {Guilherme J.M.} and Dubno, {Judy R.} and Eckert, {Mark A.} and Matthews, {Lois J.} and Schlosser, {Rodney J.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018.",

year = "2018",

month = may,

doi = "10.1177/1945892418768159",

language = "English (US)",

volume = "32",

pages = "175--180",

journal = "American Journal of Rhinology and Allergy",

issn = "1945-8924",

publisher = "OceanSide Publications Inc.",

number = "3",

}

TY - JOUR

T1 - Novel Radiographic Assessment of the Cribriform Plate

AU - Ganjaei, Kimia G.

AU - Soler, Zachary M.

AU - Mappus, Elliott D.

AU - Taylor, Robert J.

AU - Worley, Mitchell L.

AU - Mulligan, Jennifer K.

AU - Mattos, Jose L.

AU - Rowan, Nicholas R.

AU - Garcia, Guilherme J.M.

AU - Dubno, Judy R.

AU - Eckert, Mark A.

AU - Matthews, Lois J.

AU - Schlosser, Rodney J.

N1 - Publisher Copyright: © The Author(s) 2018.

PY - 2018/5

Y1 - 2018/5

N2 - Background: The cribriform plate (CP) is a common site of spontaneous cerebrospinal fluid (SCSF) leaks. Radiographic assessment of the anterior and lateral skull base has shown thinner bone in patients with SCSFs; however, prior assessment of the CP has required postmortem cadaver dissection. Objective: To develop novel radiographic techniques to assess the anatomy of the CP. Methods: Computed tomography (CT) scans were performed on cadaveric specimens. Bone density and anatomy of a predefined volume of interest of the posterior CP were assessed by two independent reviewers. CT assessment of olfactory foramina was also performed and validated using anatomic dissection of cadaver specimens. Results: Interclass correlation coefficients (ICCs) for measuring the same volume of each CP was 0.96, confirming reproducible anatomic localization. Cadaver CPs had a mean Hounsfield units of 263, indicating a mix of bone and soft tissue, and ICC was 0.98, confirming reproducible radiographic measurements. Optimal CT estimates of bone composition of CPs averaged 85% (range 76% to 96%) compared to actual anatomic dissection which averaged 84% bone (range 74% to 91%, r =.690, P =.026). Conclusion: Our novel, noninvasive CT method for assessing CP anatomy is reproducible and correlates with anatomic dissection assessing bone composition. The clinical implications of anatomic changes in the CP are an area for further study.

AB - Background: The cribriform plate (CP) is a common site of spontaneous cerebrospinal fluid (SCSF) leaks. Radiographic assessment of the anterior and lateral skull base has shown thinner bone in patients with SCSFs; however, prior assessment of the CP has required postmortem cadaver dissection. Objective: To develop novel radiographic techniques to assess the anatomy of the CP. Methods: Computed tomography (CT) scans were performed on cadaveric specimens. Bone density and anatomy of a predefined volume of interest of the posterior CP were assessed by two independent reviewers. CT assessment of olfactory foramina was also performed and validated using anatomic dissection of cadaver specimens. Results: Interclass correlation coefficients (ICCs) for measuring the same volume of each CP was 0.96, confirming reproducible anatomic localization. Cadaver CPs had a mean Hounsfield units of 263, indicating a mix of bone and soft tissue, and ICC was 0.98, confirming reproducible radiographic measurements. Optimal CT estimates of bone composition of CPs averaged 85% (range 76% to 96%) compared to actual anatomic dissection which averaged 84% bone (range 74% to 91%, r =.690, P =.026). Conclusion: Our novel, noninvasive CT method for assessing CP anatomy is reproducible and correlates with anatomic dissection assessing bone composition. The clinical implications of anatomic changes in the CP are an area for further study.

KW - anatomy

KW - bone density

KW - cerebrospinal fluid leak

KW - computed tomography

KW - craniofacial

KW - cribriform plate

KW - encephalocele

KW - ethmoid bone

KW - olfactory foramina

KW - skull base

UR - http://www.scopus.com/inward/record.url?scp=85052494063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052494063&partnerID=8YFLogxK

U2 - 10.1177/1945892418768159

DO - 10.1177/1945892418768159

M3 - Article

C2 - 29660990

AN - SCOPUS:85052494063

SN - 1945-8924

VL - 32

SP - 175

EP - 180

JO - American Journal of Rhinology and Allergy

JF - American Journal of Rhinology and Allergy

IS - 3

ER -

Novel Radiographic Assessment of the Cribriform Plate

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this