Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers

Jian Du, Jing Dai, Jun Long Liu, Theresa Dankovich

Research output: Contribution to journalArticle

Abstract

Novel polyelectrolyte beads based on carboxymethyl Konjac glucomannan (CKGM) and chitosan (CS) were prepared via electrostatic interaction. The main advantage of this system is that all procedures used were performed in aqueous medium. The pH-sensitivity of beads was characterized by fourier transformed infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The swelling characteristics of these hydrogel beads at distinct compositions as a function of pH values were investigated. It was found that the swelling rate of test beads was larger (7.4) in the alkaline medium than in the acid medium (5.2) and at pH 5.3 was the smallest (3.5). Furthermore, for the evaluation of the pH effect on drug release from the beads, we studied bovine blood proteins (BSA) release profiles at pH 1.2, 5.0 and 7.4. The pH-sensitivity of the novel polyelectrolyte complex would make an interesting protein delivery system.

Original languageEnglish (US)
Pages (from-to)1055-1061
Number of pages7
JournalReactive and Functional Polymers
Volume66
Issue number10
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Drug Carriers
Chitosan
Polyelectrolytes
swelling
Swelling
drug
pH effects
Proteins
protein
Hydrogel
calorimetry
Coulomb interactions
infrared spectroscopy
Hydrogels
Blood Proteins
Differential scanning calorimetry
Infrared spectroscopy
Blood
blood
Acids

Keywords

  • Carboxymethyl Konjac glucomannan
  • Chitosan
  • Drug carriers
  • pH-sensitivity
  • Polyelectrolyte complex

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

Cite this

Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers. / Du, Jian; Dai, Jing; Liu, Jun Long; Dankovich, Theresa.

In: Reactive and Functional Polymers, Vol. 66, No. 10, 10.2006, p. 1055-1061.

Research output: Contribution to journalArticle

Du, Jian ; Dai, Jing ; Liu, Jun Long ; Dankovich, Theresa. / Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers. In: Reactive and Functional Polymers. 2006 ; Vol. 66, No. 10. pp. 1055-1061.
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