Novel peptide-specific quantitative structure-activity relationship (QSAR) analysis applied to collagen IV peptides with antiangiogenic activity

Corban G. Rivera, Elena V. Rosca, Niranjan Pandey, Jacob E. Koskimaki, Joel S. Bader, Aleksander S Popel

Research output: Contribution to journalArticle

Abstract

Angiogenesis is the growth of new blood vessels from existing vasculature. Excessive vascularization is associated with a number of diseases including cancer. Antiangiogenic therapies have the potential to stunt cancer progression. Peptides derived from type IV collagen are potent inhibitors of angiogenesis. We wanted to gain a better understanding of collagen IV structure-activity relationships using a ligand-based approach. We developed novel peptide-specific QSAR models to study the activity of the peptides in endothelial cell proliferation, migration, and adhesion inhibition assays. We found that the models produced quantitatively accurate predictions of activity and provided insight into collagen IV derived peptide structure-activity relationships.

Original languageEnglish (US)
Pages (from-to)6492-6500
Number of pages9
JournalJournal of Medicinal Chemistry
Volume54
Issue number19
DOIs
StatePublished - Oct 13 2011

Fingerprint

Quantitative Structure-Activity Relationship
Collagen
Peptides
Structure-Activity Relationship
Angiogenesis Inhibitors
Collagen Type IV
Cell Adhesion
Cell Movement
Blood Vessels
Neoplasms
Endothelial Cells
Cell Proliferation
Ligands
Growth
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Novel peptide-specific quantitative structure-activity relationship (QSAR) analysis applied to collagen IV peptides with antiangiogenic activity. / Rivera, Corban G.; Rosca, Elena V.; Pandey, Niranjan; Koskimaki, Jacob E.; Bader, Joel S.; Popel, Aleksander S.

In: Journal of Medicinal Chemistry, Vol. 54, No. 19, 13.10.2011, p. 6492-6500.

Research output: Contribution to journalArticle

@article{2b72a3f7c702469b89e87a6b488ce8fd,
title = "Novel peptide-specific quantitative structure-activity relationship (QSAR) analysis applied to collagen IV peptides with antiangiogenic activity",
abstract = "Angiogenesis is the growth of new blood vessels from existing vasculature. Excessive vascularization is associated with a number of diseases including cancer. Antiangiogenic therapies have the potential to stunt cancer progression. Peptides derived from type IV collagen are potent inhibitors of angiogenesis. We wanted to gain a better understanding of collagen IV structure-activity relationships using a ligand-based approach. We developed novel peptide-specific QSAR models to study the activity of the peptides in endothelial cell proliferation, migration, and adhesion inhibition assays. We found that the models produced quantitatively accurate predictions of activity and provided insight into collagen IV derived peptide structure-activity relationships.",
author = "Rivera, {Corban G.} and Rosca, {Elena V.} and Niranjan Pandey and Koskimaki, {Jacob E.} and Bader, {Joel S.} and Popel, {Aleksander S}",
year = "2011",
month = "10",
day = "13",
doi = "10.1021/jm200114f",
language = "English (US)",
volume = "54",
pages = "6492--6500",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "19",

}

TY - JOUR

T1 - Novel peptide-specific quantitative structure-activity relationship (QSAR) analysis applied to collagen IV peptides with antiangiogenic activity

AU - Rivera, Corban G.

AU - Rosca, Elena V.

AU - Pandey, Niranjan

AU - Koskimaki, Jacob E.

AU - Bader, Joel S.

AU - Popel, Aleksander S

PY - 2011/10/13

Y1 - 2011/10/13

N2 - Angiogenesis is the growth of new blood vessels from existing vasculature. Excessive vascularization is associated with a number of diseases including cancer. Antiangiogenic therapies have the potential to stunt cancer progression. Peptides derived from type IV collagen are potent inhibitors of angiogenesis. We wanted to gain a better understanding of collagen IV structure-activity relationships using a ligand-based approach. We developed novel peptide-specific QSAR models to study the activity of the peptides in endothelial cell proliferation, migration, and adhesion inhibition assays. We found that the models produced quantitatively accurate predictions of activity and provided insight into collagen IV derived peptide structure-activity relationships.

AB - Angiogenesis is the growth of new blood vessels from existing vasculature. Excessive vascularization is associated with a number of diseases including cancer. Antiangiogenic therapies have the potential to stunt cancer progression. Peptides derived from type IV collagen are potent inhibitors of angiogenesis. We wanted to gain a better understanding of collagen IV structure-activity relationships using a ligand-based approach. We developed novel peptide-specific QSAR models to study the activity of the peptides in endothelial cell proliferation, migration, and adhesion inhibition assays. We found that the models produced quantitatively accurate predictions of activity and provided insight into collagen IV derived peptide structure-activity relationships.

UR - http://www.scopus.com/inward/record.url?scp=80053915567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053915567&partnerID=8YFLogxK

U2 - 10.1021/jm200114f

DO - 10.1021/jm200114f

M3 - Article

C2 - 21866962

AN - SCOPUS:80053915567

VL - 54

SP - 6492

EP - 6500

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 19

ER -