Novel packages of viral and self-antigens are generated during apoptosis

Research output: Contribution to journalArticle

Abstract

Immune context is an essential determinant of the host response to potential autoantigens. The clustering of the autoantigens targeted in systemic lupus erythematosus within surface blebs of apoptotic cells generates high concentrations of autoantigen within discrete subcellular packages. We demonstrate here that when apoptosis is induced by Sindbis virus infection, viral antigens and autoantigens cocluster exclusively in small surface blebs of apoptotic cells. The surface of these blebs is rich in vital glycoproteins, and virions can be seen blebbing from their surface. We propose that these blebs of mixed foreign and self-origin define a novel immune context that may challenge self-tolerance.

Original languageEnglish (US)
Pages (from-to)1557-1561
Number of pages5
JournalJournal of Experimental Medicine
Volume181
Issue number4
DOIs
StatePublished - Apr 1 1995

Fingerprint

Viral Antigens
Autoantigens
Blister
Apoptosis
Sindbis Virus
Self Tolerance
Virus Diseases
Virion
Systemic Lupus Erythematosus
Cluster Analysis
Glycoproteins

ASJC Scopus subject areas

  • Immunology

Cite this

Novel packages of viral and self-antigens are generated during apoptosis. / Rosen, Antony; Casciola Rosen, Livia A; Ahearn, Joseph.

In: Journal of Experimental Medicine, Vol. 181, No. 4, 01.04.1995, p. 1557-1561.

Research output: Contribution to journalArticle

@article{750dbb8a7fde43a6826c9951d4690c71,
title = "Novel packages of viral and self-antigens are generated during apoptosis",
abstract = "Immune context is an essential determinant of the host response to potential autoantigens. The clustering of the autoantigens targeted in systemic lupus erythematosus within surface blebs of apoptotic cells generates high concentrations of autoantigen within discrete subcellular packages. We demonstrate here that when apoptosis is induced by Sindbis virus infection, viral antigens and autoantigens cocluster exclusively in small surface blebs of apoptotic cells. The surface of these blebs is rich in vital glycoproteins, and virions can be seen blebbing from their surface. We propose that these blebs of mixed foreign and self-origin define a novel immune context that may challenge self-tolerance.",
author = "Antony Rosen and {Casciola Rosen}, {Livia A} and Joseph Ahearn",
year = "1995",
month = "4",
day = "1",
doi = "10.1084/jem.181.4.1557",
language = "English (US)",
volume = "181",
pages = "1557--1561",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "4",

}

TY - JOUR

T1 - Novel packages of viral and self-antigens are generated during apoptosis

AU - Rosen, Antony

AU - Casciola Rosen, Livia A

AU - Ahearn, Joseph

PY - 1995/4/1

Y1 - 1995/4/1

N2 - Immune context is an essential determinant of the host response to potential autoantigens. The clustering of the autoantigens targeted in systemic lupus erythematosus within surface blebs of apoptotic cells generates high concentrations of autoantigen within discrete subcellular packages. We demonstrate here that when apoptosis is induced by Sindbis virus infection, viral antigens and autoantigens cocluster exclusively in small surface blebs of apoptotic cells. The surface of these blebs is rich in vital glycoproteins, and virions can be seen blebbing from their surface. We propose that these blebs of mixed foreign and self-origin define a novel immune context that may challenge self-tolerance.

AB - Immune context is an essential determinant of the host response to potential autoantigens. The clustering of the autoantigens targeted in systemic lupus erythematosus within surface blebs of apoptotic cells generates high concentrations of autoantigen within discrete subcellular packages. We demonstrate here that when apoptosis is induced by Sindbis virus infection, viral antigens and autoantigens cocluster exclusively in small surface blebs of apoptotic cells. The surface of these blebs is rich in vital glycoproteins, and virions can be seen blebbing from their surface. We propose that these blebs of mixed foreign and self-origin define a novel immune context that may challenge self-tolerance.

UR - http://www.scopus.com/inward/record.url?scp=0028923130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028923130&partnerID=8YFLogxK

U2 - 10.1084/jem.181.4.1557

DO - 10.1084/jem.181.4.1557

M3 - Article

VL - 181

SP - 1557

EP - 1561

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 4

ER -