Novel oral anticoagulants in development: Dabigatran, rivaroxaban, and apixaban

Maryam Sattari, David T. Lowenthal

Research output: Contribution to journalReview articlepeer-review

Abstract

Venous thromboembolic disease, including deep vein thrombosis and pulmonary embolism, is a cause of significant mortality and morbidity. For several decades, anticoagulant options for the treatment and prevention of thrombosis have been limited mainly to agents such as unfractionated heparin and oral vitamin K antagonists, such as warfarin. Although these therapies have proven benefits, they also have important limitations that result in their underuse in routine clinical practice. A variety of novel anticoagulants with improved pharmacologic and clinical profiles are in development, offering benefits over traditional therapies. Specifically, progress has been made in the development of small molecule factor Xa inhibitors and thrombin inhibitors. With their potentially consistent and predictable clinical profile, oral formulation, and decreased need for coagulation monitoring, these new agents will likely increase the use and duration of anticoagulation treatment in thromboembolic disorders and reduce the burden associated with long-term management.

Original languageEnglish (US)
Pages (from-to)332-338
Number of pages7
JournalAmerican Journal of Therapeutics
Volume18
Issue number4
DOIs
StatePublished - Jul 1 2011

Keywords

  • oral anticoagulants

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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