Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia

Cerine Jeanty, Shaun M. Kunisaki, Tippi C. MacKenzie

Research output: Contribution to journalReview articlepeer-review

Abstract

This review focuses on the emerging field of non-surgical in-utero therapies in the management of fetal pulmonary hypoplasia and pulmonary hypertension associated with congenital diaphragmatic hernia (CDH). These experimental approaches include pharmacologic as well as stem-cell-based strategies. Current barriers of non-surgical therapies toward clinical translation are emphasized. As the severity of CDH will likely influence the efficacy of any in-utero therapy, the current status of prenatal imaging and the role of novel biomarkers, especially those related to fetal inflammation, are also reviewed.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalSeminars in Fetal and Neonatal Medicine
Volume19
Issue number6
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • Congenital diaphragmatic hernia
  • Prenatal pharmacologic treatment
  • Prenatal stem cell therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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