Novel neuropeptide Y1 and Y5 receptor gene variants: Associations with serum triglyceride and high-density lipoprotein cholesterol levels

J. B. Blumenthal, R. E. Andersen, B. D. Mitchell, M. J. Seibert, H. Yang, H. Herzog, B. A. Beamer, S. C. Franckowiak, Jeremy D Walston

Research output: Contribution to journalArticle

Abstract

Neuropeptide Y (NPY) appears to play a critical role in the integration of appetite and energy expenditure through NPY Y1 and Y5 receptor subtypes. Moreover, the NPY Y1 receptor is highly expressed on human adipocytes, where it inhibits lipolysis. The genes encoding these receptors are transcribed co-ordinately in opposite directions from a common promoter in a region of chromosome 4 that has been previously linked to triglyceride and small low-density lipoprotein (LDL) particle concentration. Therefore, the purpose of this investigation was to examine the relationship between polymorphisms in the genes encoding NPY Y1 and Y5 and the development of obesity and dyslipidemia. We screened the promoter and coding regions and identified four polymorphic variants. One of these, a cytosine to thymine (C→T) substitution in the untranslated region between the genes for NPY Y1 and Y5 (allele frequency 0.11), was significantly associated with both lower fasting triglyceride level (152 vs 125mg/dl), and higher high-density lipoprotein (HDL) concentrations (49 vs 45mg/dl) (p

Original languageEnglish (US)
Pages (from-to)196-202
Number of pages7
JournalClinical Genetics
Volume62
Issue number3
DOIs
StatePublished - Sep 1 2002

Fingerprint

Neuropeptide Y
HDL Cholesterol
Triglycerides
Serum
Genes
Untranslated Regions
Chromosomes, Human, Pair 4
Thymine
Lipolysis
Cytosine
Appetite
HDL Lipoproteins
Dyslipidemias
Adipocytes
Genetic Promoter Regions
Gene Frequency
Energy Metabolism
Fasting
Obesity
neuropeptide Y5 receptor

Keywords

  • HDL cholesterol
  • Lipid metabolism
  • Polymorphism
  • Triglyceride

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Novel neuropeptide Y1 and Y5 receptor gene variants : Associations with serum triglyceride and high-density lipoprotein cholesterol levels. / Blumenthal, J. B.; Andersen, R. E.; Mitchell, B. D.; Seibert, M. J.; Yang, H.; Herzog, H.; Beamer, B. A.; Franckowiak, S. C.; Walston, Jeremy D.

In: Clinical Genetics, Vol. 62, No. 3, 01.09.2002, p. 196-202.

Research output: Contribution to journalArticle

Blumenthal, JB, Andersen, RE, Mitchell, BD, Seibert, MJ, Yang, H, Herzog, H, Beamer, BA, Franckowiak, SC & Walston, JD 2002, 'Novel neuropeptide Y1 and Y5 receptor gene variants: Associations with serum triglyceride and high-density lipoprotein cholesterol levels', Clinical Genetics, vol. 62, no. 3, pp. 196-202. https://doi.org/10.1034/j.1399-0004.2002.620302.x
Blumenthal, J. B. ; Andersen, R. E. ; Mitchell, B. D. ; Seibert, M. J. ; Yang, H. ; Herzog, H. ; Beamer, B. A. ; Franckowiak, S. C. ; Walston, Jeremy D. / Novel neuropeptide Y1 and Y5 receptor gene variants : Associations with serum triglyceride and high-density lipoprotein cholesterol levels. In: Clinical Genetics. 2002 ; Vol. 62, No. 3. pp. 196-202.
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