Novel nanoparticles formed via self-assembly of poly(ethylene glycol-b-sebacic anhydride) and their degradation in water

Chi Wu, Jie Fu, Yue Zhao

Research output: Contribution to journalArticle


A novel diblock copolymer, poly(ethylene oxide-b-sebacic acid) (PEO-b-PSA), was prepared by polycondensation. Its self-assembly in water via a microphase inversion resulted in narrowly distributed stable polymeric nanoparticles with a size of approximately 70 nm. Such formed nanoparticles had a core-shell nanostructure with the insoluble hydrophobic PSA blocks as the core and the soluble hydrophilic PEO blocks as the protective shell. The core was degradable, and its degradation led to the disintegration of the nanoparticle. The structure of the nanostructure and the degradation kinetics were investigated by a combination of static and dynamic laser light scattering. Our results indicated that the degradation was a first-order reaction, and the degradation rate increases with the dispersion temperature.

Original languageEnglish (US)
Pages (from-to)9040-9043
Number of pages4
Issue number24
StatePublished - Nov 28 2000


ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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