Novel Mutations Widen the Phenotypic Spectrum of Slow Skeletal/β-Cardiac Myosin (MYH7) Distal Myopathy

Phillipa J. Lamont, William Wallefeld, David Hilton-Jones, Bjarne Udd, Zohar Argov, Alexandru C. Barboi, Carsten Bonneman, Kym M. Boycott, Kate Bushby, Anne M. Connolly, Nicholas Davies, Alan H. Beggs, Gerald F. Cox, Jahannaz Dastgir, Elizabeth T. Dechene, Rebecca Gooding, Heinz Jungbluth, Nuria Muelas, Johanna Palmio, Sini Penttilä & 10 others Eric Schmedding, Tiina Suominen, Volker Straub, Christopher Staples, Peter Y K Van den Bergh, Juan J. Vilchez, Kathryn Rae Wagner, Patricia G. Wheeler, Elizabeth Wraige, Nigel G. Laing

Research output: Contribution to journalArticle

Abstract

Laing early onset distal myopathy and myosin storage myopathy are caused by mutations of slow skeletal/β-cardiac myosin heavy chain encoded by the gene MYH7, as is a common form of familial hypertrophic/dilated cardiomyopathy. The mechanisms by which different phenotypes are produced by mutations in MYH7, even in the same region of the gene, are not known. To explore the clinical spectrum and pathobiology, we screened the MYH7 gene in 88 patients from 21 previously unpublished families presenting with distal or generalized skeletal muscle weakness, with or without cardiac involvement. Twelve novel mutations have been identified in thirteen families. In one of these families, the father of the proband was found to be a mosaic for the MYH7 mutation. In eight cases, de novo mutation appeared to have occurred, which was proven in four. The presenting complaint was footdrop, sometimes leading to delayed walking or tripping, in members of 17 families (81%), with other presentations including cardiomyopathy in infancy, generalized floppiness, and scoliosis. Cardiac involvement as well as skeletal muscle weakness was identified in nine of 21 families. Spinal involvement such as scoliosis or rigidity was identified in 12 (57%). This report widens the clinical and pathological phenotypes, and the genetics of MYH7 mutations leading to skeletal muscle diseases.

Original languageEnglish (US)
Pages (from-to)868-879
Number of pages12
JournalHuman Mutation
Volume35
Issue number7
DOIs
StatePublished - 2014

Fingerprint

Distal Myopathies
Cardiac Myosins
Mutation
Skeletal Muscle
Muscle Weakness
Scoliosis
Familial Hypertrophic Cardiomyopathy
Genes
Phenotype
Myosin Heavy Chains
Cardiomyopathies
Fathers
Walking
Myocardium

Keywords

  • Laing distal myopathy
  • MPD1
  • MYH7

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Lamont, P. J., Wallefeld, W., Hilton-Jones, D., Udd, B., Argov, Z., Barboi, A. C., ... Laing, N. G. (2014). Novel Mutations Widen the Phenotypic Spectrum of Slow Skeletal/β-Cardiac Myosin (MYH7) Distal Myopathy. Human Mutation, 35(7), 868-879. https://doi.org/10.1002/humu.22553

Novel Mutations Widen the Phenotypic Spectrum of Slow Skeletal/β-Cardiac Myosin (MYH7) Distal Myopathy. / Lamont, Phillipa J.; Wallefeld, William; Hilton-Jones, David; Udd, Bjarne; Argov, Zohar; Barboi, Alexandru C.; Bonneman, Carsten; Boycott, Kym M.; Bushby, Kate; Connolly, Anne M.; Davies, Nicholas; Beggs, Alan H.; Cox, Gerald F.; Dastgir, Jahannaz; Dechene, Elizabeth T.; Gooding, Rebecca; Jungbluth, Heinz; Muelas, Nuria; Palmio, Johanna; Penttilä, Sini; Schmedding, Eric; Suominen, Tiina; Straub, Volker; Staples, Christopher; Van den Bergh, Peter Y K; Vilchez, Juan J.; Wagner, Kathryn Rae; Wheeler, Patricia G.; Wraige, Elizabeth; Laing, Nigel G.

In: Human Mutation, Vol. 35, No. 7, 2014, p. 868-879.

Research output: Contribution to journalArticle

Lamont, PJ, Wallefeld, W, Hilton-Jones, D, Udd, B, Argov, Z, Barboi, AC, Bonneman, C, Boycott, KM, Bushby, K, Connolly, AM, Davies, N, Beggs, AH, Cox, GF, Dastgir, J, Dechene, ET, Gooding, R, Jungbluth, H, Muelas, N, Palmio, J, Penttilä, S, Schmedding, E, Suominen, T, Straub, V, Staples, C, Van den Bergh, PYK, Vilchez, JJ, Wagner, KR, Wheeler, PG, Wraige, E & Laing, NG 2014, 'Novel Mutations Widen the Phenotypic Spectrum of Slow Skeletal/β-Cardiac Myosin (MYH7) Distal Myopathy', Human Mutation, vol. 35, no. 7, pp. 868-879. https://doi.org/10.1002/humu.22553
Lamont, Phillipa J. ; Wallefeld, William ; Hilton-Jones, David ; Udd, Bjarne ; Argov, Zohar ; Barboi, Alexandru C. ; Bonneman, Carsten ; Boycott, Kym M. ; Bushby, Kate ; Connolly, Anne M. ; Davies, Nicholas ; Beggs, Alan H. ; Cox, Gerald F. ; Dastgir, Jahannaz ; Dechene, Elizabeth T. ; Gooding, Rebecca ; Jungbluth, Heinz ; Muelas, Nuria ; Palmio, Johanna ; Penttilä, Sini ; Schmedding, Eric ; Suominen, Tiina ; Straub, Volker ; Staples, Christopher ; Van den Bergh, Peter Y K ; Vilchez, Juan J. ; Wagner, Kathryn Rae ; Wheeler, Patricia G. ; Wraige, Elizabeth ; Laing, Nigel G. / Novel Mutations Widen the Phenotypic Spectrum of Slow Skeletal/β-Cardiac Myosin (MYH7) Distal Myopathy. In: Human Mutation. 2014 ; Vol. 35, No. 7. pp. 868-879.
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AU - Wallefeld, William

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AU - Udd, Bjarne

AU - Argov, Zohar

AU - Barboi, Alexandru C.

AU - Bonneman, Carsten

AU - Boycott, Kym M.

AU - Bushby, Kate

AU - Connolly, Anne M.

AU - Davies, Nicholas

AU - Beggs, Alan H.

AU - Cox, Gerald F.

AU - Dastgir, Jahannaz

AU - Dechene, Elizabeth T.

AU - Gooding, Rebecca

AU - Jungbluth, Heinz

AU - Muelas, Nuria

AU - Palmio, Johanna

AU - Penttilä, Sini

AU - Schmedding, Eric

AU - Suominen, Tiina

AU - Straub, Volker

AU - Staples, Christopher

AU - Van den Bergh, Peter Y K

AU - Vilchez, Juan J.

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AU - Wheeler, Patricia G.

AU - Wraige, Elizabeth

AU - Laing, Nigel G.

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