Novel method for imaging biodegradable polymeric microparticles using MRI: Application toward monitoring drug delivery

Hunter H. Chen; Catherine Le Visage; Bensheng Qiu; Xiangying Du; Ronald Ouwerkerk; Kam W. Leong; Xiaoming Yang

doi:10.1109/ISBI.2002.1029214

Novel method for imaging biodegradable polymeric microparticles using MRI: Application toward monitoring drug delivery

Hunter H. Chen, Catherine Le Visage, Bensheng Qiu, Xiangying Du, Ronald Ouwerkerk, Kam W. Leong, Xiaoming Yang

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We have developed a novel, non-invasive method to monitor intravesical drug delivery to the bladder using MRI by encapsulating Gd-DTPA into biodegradable polymeric microparticles. In in vitro experiments, Gd-DTPA-loaded particles could be differentiated from blank particles and water. Images from in vivo experiments demonstrated that particle distribution in the bladder could be assessed and that signal intensity appeared to correspond with particle population. The microparticles were adherent to the urothelium and were detectable by MRI for at least 4 days after the initial instillation due to their muco-adhesiveness and stability. This non-invasive method enables the evaluation of local particle distribution in vivo, thereby enhancing the value of particle-based drug delivery systems.

Original language	English (US)
Title of host publication	Proceedings - International Symposium on Biomedical Imaging
Publisher	IEEE Computer Society
Pages	145-148
Number of pages	4
Volume	2002-January
ISBN (Print)	078037584X
DOIs	https://doi.org/10.1109/ISBI.2002.1029214
State	Published - 2002
Event	IEEE International Symposium on Biomedical Imaging, ISBI 2002 - Washington, United States Duration: Jul 7 2002 → Jul 10 2002

Other

Other	IEEE International Symposium on Biomedical Imaging, ISBI 2002
Country/Territory	United States
City	Washington
Period	7/7/02 → 7/10/02

ASJC Scopus subject areas

Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1109/ISBI.2002.1029214

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Chen, H. H., Le Visage, C., Qiu, B., Du, X., Ouwerkerk, R., Leong, K. W., & Yang, X. (2002). Novel method for imaging biodegradable polymeric microparticles using MRI: Application toward monitoring drug delivery. In Proceedings - International Symposium on Biomedical Imaging (Vol. 2002-January, pp. 145-148). Article 1029214 IEEE Computer Society. https://doi.org/10.1109/ISBI.2002.1029214

Novel method for imaging biodegradable polymeric microparticles using MRI: Application toward monitoring drug delivery. / Chen, Hunter H.; Le Visage, Catherine; Qiu, Bensheng et al.
Proceedings - International Symposium on Biomedical Imaging. Vol. 2002-January IEEE Computer Society, 2002. p. 145-148 1029214.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chen, HH, Le Visage, C, Qiu, B, Du, X, Ouwerkerk, R, Leong, KW & Yang, X 2002, Novel method for imaging biodegradable polymeric microparticles using MRI: Application toward monitoring drug delivery. in Proceedings - International Symposium on Biomedical Imaging. vol. 2002-January, 1029214, IEEE Computer Society, pp. 145-148, IEEE International Symposium on Biomedical Imaging, ISBI 2002, Washington, United States, 7/7/02. https://doi.org/10.1109/ISBI.2002.1029214

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title = "Novel method for imaging biodegradable polymeric microparticles using MRI: Application toward monitoring drug delivery",

abstract = "We have developed a novel, non-invasive method to monitor intravesical drug delivery to the bladder using MRI by encapsulating Gd-DTPA into biodegradable polymeric microparticles. In in vitro experiments, Gd-DTPA-loaded particles could be differentiated from blank particles and water. Images from in vivo experiments demonstrated that particle distribution in the bladder could be assessed and that signal intensity appeared to correspond with particle population. The microparticles were adherent to the urothelium and were detectable by MRI for at least 4 days after the initial instillation due to their muco-adhesiveness and stability. This non-invasive method enables the evaluation of local particle distribution in vivo, thereby enhancing the value of particle-based drug delivery systems.",

author = "Chen, {Hunter H.} and {Le Visage}, Catherine and Bensheng Qiu and Xiangying Du and Ronald Ouwerkerk and Leong, {Kam W.} and Xiaoming Yang",

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AU - Ouwerkerk, Ronald

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N2 - We have developed a novel, non-invasive method to monitor intravesical drug delivery to the bladder using MRI by encapsulating Gd-DTPA into biodegradable polymeric microparticles. In in vitro experiments, Gd-DTPA-loaded particles could be differentiated from blank particles and water. Images from in vivo experiments demonstrated that particle distribution in the bladder could be assessed and that signal intensity appeared to correspond with particle population. The microparticles were adherent to the urothelium and were detectable by MRI for at least 4 days after the initial instillation due to their muco-adhesiveness and stability. This non-invasive method enables the evaluation of local particle distribution in vivo, thereby enhancing the value of particle-based drug delivery systems.

AB - We have developed a novel, non-invasive method to monitor intravesical drug delivery to the bladder using MRI by encapsulating Gd-DTPA into biodegradable polymeric microparticles. In in vitro experiments, Gd-DTPA-loaded particles could be differentiated from blank particles and water. Images from in vivo experiments demonstrated that particle distribution in the bladder could be assessed and that signal intensity appeared to correspond with particle population. The microparticles were adherent to the urothelium and were detectable by MRI for at least 4 days after the initial instillation due to their muco-adhesiveness and stability. This non-invasive method enables the evaluation of local particle distribution in vivo, thereby enhancing the value of particle-based drug delivery systems.

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Novel method for imaging biodegradable polymeric microparticles using MRI: Application toward monitoring drug delivery

Abstract

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