Novel method for imaging biodegradable polymeric microparticles using MRI: Application toward monitoring drug delivery

Hunter H. Chen, Catherine Le Visage, Bensheng Qiu, Xiangying Du, Ronald Ouwerkerk, Kam W. Leong, Xiaoming Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a novel, non-invasive method to monitor intravesical drug delivery to the bladder using MRI by encapsulating Gd-DTPA into biodegradable polymeric microparticles. In in vitro experiments, Gd-DTPA-loaded particles could be differentiated from blank particles and water. Images from in vivo experiments demonstrated that particle distribution in the bladder could be assessed and that signal intensity appeared to correspond with particle population. The microparticles were adherent to the urothelium and were detectable by MRI for at least 4 days after the initial instillation due to their muco-adhesiveness and stability. This non-invasive method enables the evaluation of local particle distribution in vivo, thereby enhancing the value of particle-based drug delivery systems.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages145-148
Number of pages4
Volume2002-January
ISBN (Print)078037584X
DOIs
StatePublished - 2002
EventIEEE International Symposium on Biomedical Imaging, ISBI 2002 - Washington, United States
Duration: Jul 7 2002Jul 10 2002

Other

OtherIEEE International Symposium on Biomedical Imaging, ISBI 2002
CountryUnited States
CityWashington
Period7/7/027/10/02

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Chen, H. H., Le Visage, C., Qiu, B., Du, X., Ouwerkerk, R., Leong, K. W., & Yang, X. (2002). Novel method for imaging biodegradable polymeric microparticles using MRI: Application toward monitoring drug delivery. In Proceedings - International Symposium on Biomedical Imaging (Vol. 2002-January, pp. 145-148). [1029214] IEEE Computer Society. https://doi.org/10.1109/ISBI.2002.1029214