Novel markers of oxidative stress in actively progressive HIV dementia

Ned Sacktor, Norman Haughey, Roy Cutler, Anita Tamara, Jadwiga Turchan, Carlos Pardo, Diana Vargas, Avindra Nath

Research output: Contribution to journalArticle

Abstract

Oxidative stress leads to the production of reactive oxygen species that can attack lipid membranes resulting in cellular dysfunction and death. Cellular redox state is closely linked to ceramide, sphingomyelin, and 4-hydroxynonenal (HNE) levels. We describe data showing increased levels of these oxidative stress markers in HIV encephalitis. In addition, actively progressing HIV dementia is associated with increases in HNE and ceramide, while inactive HIV dementia is associated with increases in sphingomyelin. These markers may be useful for distinguishing between different clinical phenotypes of HIV dementia.

Original languageEnglish (US)
Pages (from-to)176-184
Number of pages9
JournalJournal of Neuroimmunology
Volume157
Issue number1-2 SPEC. ISS.
DOIs
StatePublished - Dec 1 2004

Keywords

  • Ceramide
  • Dementia
  • HIV
  • Oxidative stress
  • Sphingomyelin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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