Novel Functions and Virus–Host Interactions Implicated in Pathogenesis and Replication of Human Herpesvirus 8

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human herpesvirus 8 (HHV-8) is classified as a γ2-herpesvirus and is related to Epstein–Barr virus (EBV), a γ1-herpesvirus. One important aspect of the γ-herpesviruses is their association with neoplasia, either naturally or in animal model systems. HHV-8 is associated with B-cell-derived primary effusion lymphoma (PEL) and multicentric Castleman’s disease (MCD), endothelial-derived Kaposi’s sarcoma (KS), and KSHV inflammatory cytokine syndrome (KICS). EBV is also associated with a number of B-cell malignancies, such as Burkitt’s lymphoma, Hodgkin’s lymphoma, and posttransplant lymphoproliferative disease, in addition to epithelial nasopharyngeal and gastric carcinomas. Despite the similarities between these viruses and their associated malignancies, the particular protein functions and activities involved in key aspects of virus biology and neoplastic transformation appear to be quite distinct. Indeed, HHV-8 specifies a number of proteins for which counterparts had not previously been identified in EBV, other herpesviruses, or even viruses in general, and these proteins are believed to play vital functions in virus biology and to be involved centrally in viral pathogenesis. Additionally, a set of microRNAs encoded by HHV-8 appears to modulate the expression of multiple host proteins to provide conditions conductive to virus persistence within the host and possibly contributing to HHV-8-induced neoplasia. Here, we review the molecular biology underlying these novel virus–host interactions and their potential roles in both virus biology and virus-associated disease.

Original languageEnglish (US)
Title of host publicationRecent Results in Cancer Research
PublisherSpringer Science and Business Media Deutschland GmbH
Pages245-301
Number of pages57
DOIs
StatePublished - 2021

Publication series

NameRecent Results in Cancer Research
Volume217
ISSN (Print)0080-0015
ISSN (Electronic)2197-6767

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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