Novel Functional Renal PET Imaging with 18F-FDS in Human Subjects

Rudolf A. Werner, Alvaro Ordonez Suarez, Julian Sanchez-Bautista, Charles Marcus, Constantin Lapa, Steven Rowe, Martin Gilbert Pomper, Jeffrey Pettit Leal, Martin Lodge, Mehrbod Som Som Javadi, Sanjay Jain, Takahiro Higuchi

Research output: Contribution to journalArticle

Abstract

The novel PET probe 2-deoxy-2-18F-fluoro-d-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. 18F-FDS was produced by a simple 1-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.

Original languageEnglish (US)
Pages (from-to)410-411
Number of pages2
JournalClinical nuclear medicine
Volume44
Issue number5
DOIs
StatePublished - May 1 2019

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Sorbitol
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Keywords

  • 18F-FDS
  • 2-deoxy-2-18F-fluoro-d-sorbitol
  • kidney
  • PET
  • renal imaging
  • split renal function

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Novel Functional Renal PET Imaging with 18F-FDS in Human Subjects. / Werner, Rudolf A.; Ordonez Suarez, Alvaro; Sanchez-Bautista, Julian; Marcus, Charles; Lapa, Constantin; Rowe, Steven; Pomper, Martin Gilbert; Leal, Jeffrey Pettit; Lodge, Martin; Javadi, Mehrbod Som Som; Jain, Sanjay; Higuchi, Takahiro.

In: Clinical nuclear medicine, Vol. 44, No. 5, 01.05.2019, p. 410-411.

Research output: Contribution to journalArticle

Werner, Rudolf A. ; Ordonez Suarez, Alvaro ; Sanchez-Bautista, Julian ; Marcus, Charles ; Lapa, Constantin ; Rowe, Steven ; Pomper, Martin Gilbert ; Leal, Jeffrey Pettit ; Lodge, Martin ; Javadi, Mehrbod Som Som ; Jain, Sanjay ; Higuchi, Takahiro. / Novel Functional Renal PET Imaging with 18F-FDS in Human Subjects. In: Clinical nuclear medicine. 2019 ; Vol. 44, No. 5. pp. 410-411.
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