Novel electrode design for potentially painless internal defibrillation also allows for successful external defibrillation

Venku Jayanti, Menekhem M. Zviman, Saman Nazarian, Henry R Halperin, Ronald D Berger

Research output: Contribution to journalArticle

Abstract

Painless Internal Defibrillation. Background: Implantable cardioverter defibrillators (ICDs) save lives, but the defibrillation shocks delivered by these devices produce substantial pain, presumably due to skeletal muscle activation. In this study, we tested an electrode system composed of epicardial panels designed to shield skeletal muscles from internal defibrillation, but allow penetration of an external electric field to enable external defibrillation when required. Methods and Results: Eleven adult mongrel dogs were studied under general anesthesia. Internal defibrillation threshold (DFT) and shock-induced skeletal muscle force at various biphasic shock strengths were compared between two electrode configurations: (1) a transvenous coil placed in the right ventricle (RV) as cathode and a dummy can placed subcutaneously in the left infraclavicular fossa as anode (control configuration) and (2) RV coil as cathode and the multielectrode epicardial sock with the panels connected together as anode (sock-connected). External DFT was also tested with these electrode configurations, as well as with the epicardial sock present, but with panels disconnected from each other (sock-disconnected). Internal DFT was higher with sock-connected than control (24 ± 7 J vs. 16 ± 6 J, P <0.02), but muscle contraction force at DFT was greatly reduced (1.3 ± 1.3 kg vs. 10.6 ± 2.2 kg, P <0.0001). External defibrillation was never successful, even at 360 J, with sock-connected, while always possible with sock-disconnected. Conclusion: Internal defibrillation with greatly reduced skeletal muscle stimulation can be achieved using a novel electrode system that also preserves the ability to externally defibrillate when required. This system may provide a means for painless ICD therapy.

Original languageEnglish (US)
Pages (from-to)1095-1100
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume18
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

Electrodes
Skeletal Muscle
Shock
Implantable Defibrillators
Heart Ventricles
Aptitude
Muscle Contraction
General Anesthesia
Dogs
Pain
Equipment and Supplies

Keywords

  • Cardiac fibrillation/defibrillation
  • Implantable devices
  • Ventricular tachycardia/fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Novel electrode design for potentially painless internal defibrillation also allows for successful external defibrillation. / Jayanti, Venku; Zviman, Menekhem M.; Nazarian, Saman; Halperin, Henry R; Berger, Ronald D.

In: Journal of Cardiovascular Electrophysiology, Vol. 18, No. 10, 10.2007, p. 1095-1100.

Research output: Contribution to journalArticle

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abstract = "Painless Internal Defibrillation. Background: Implantable cardioverter defibrillators (ICDs) save lives, but the defibrillation shocks delivered by these devices produce substantial pain, presumably due to skeletal muscle activation. In this study, we tested an electrode system composed of epicardial panels designed to shield skeletal muscles from internal defibrillation, but allow penetration of an external electric field to enable external defibrillation when required. Methods and Results: Eleven adult mongrel dogs were studied under general anesthesia. Internal defibrillation threshold (DFT) and shock-induced skeletal muscle force at various biphasic shock strengths were compared between two electrode configurations: (1) a transvenous coil placed in the right ventricle (RV) as cathode and a dummy can placed subcutaneously in the left infraclavicular fossa as anode (control configuration) and (2) RV coil as cathode and the multielectrode epicardial sock with the panels connected together as anode (sock-connected). External DFT was also tested with these electrode configurations, as well as with the epicardial sock present, but with panels disconnected from each other (sock-disconnected). Internal DFT was higher with sock-connected than control (24 ± 7 J vs. 16 ± 6 J, P <0.02), but muscle contraction force at DFT was greatly reduced (1.3 ± 1.3 kg vs. 10.6 ± 2.2 kg, P <0.0001). External defibrillation was never successful, even at 360 J, with sock-connected, while always possible with sock-disconnected. Conclusion: Internal defibrillation with greatly reduced skeletal muscle stimulation can be achieved using a novel electrode system that also preserves the ability to externally defibrillate when required. This system may provide a means for painless ICD therapy.",
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