Novel dimensions of piRNAs in cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

Piwi-interacting RNAs (piRNAs), a newly identified class of small non-coding RNAs, direct the Piwi-dependent transposon silencing, heterochromatin modification and germ cell maintenance. Owing to our limited knowledge regarding their biogenesis, piRNAs are considered as the most mysterious class of small regulatory RNAs, particularly in pathogenesis such as tumorigenesis. Recently, several lines of evidence have emerged to suggest that piRNAs may be dis-regulated and play crucial roles in tumorigenesis in previously unsuspected ways. In this prospective piece, we will discuss the emerging insights into the potential novel roles of piRNAs in carcinogenesis and highlight their potential implications in cancer detection, classification and therapy.

Original languageEnglish (US)
Pages (from-to)46-52
Number of pages7
JournalCancer Letters
Volume336
Issue number1
DOIs
StatePublished - Aug 9 2013
Externally publishedYes

Keywords

  • Cancer
  • Diagnosis
  • PIWI-interacting RNAs
  • Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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