Novel contrast-enhanced ultrasound evaluation in neonatal hypoxic ischemic injury: Clinical application and future directions

Misun Hwang, Robert M. De Jong, Stephan Herman, Renee Boss, Becky Riggs, Aylin Tekes-Brady, Melissa Spevak, Andrea Poretti, Bruno P. Soares, Christopher R. Bailey, Emily Dunn, Samuel S. Shin, Shai Shrot, Thierry A.G.M. Huisman

Research output: Contribution to journalArticlepeer-review

Abstract

Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, and improved survival of neonates with hypoxic ischemic injury. Contrast-enhanced ultrasound (US) imaging is a novel imaging technique in which intravenously injected gas-filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast-enhanced US imaging in 2 neonates with hypoxic ischemic injury and future directions on developing quantitative contrast-enhanced US techniques for improved characterization of perfusion abnormalities. The importance of studying the temporal evolution of brain perfusion in neonatal hypoxic ischemic injury is also highlighted.

Original languageEnglish (US)
Pages (from-to)2379-2386
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume36
Issue number11
DOIs
StatePublished - Nov 2017

Keywords

  • Contrast-enhanced ultrasound
  • Hypoxic ischemic injury
  • Microbubbles
  • Neonates
  • Neuroimaging
  • Pediatric ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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