Novel approaches to treatment of glomerulonephritis

George M. Nassar, Kamal F. Badr

Research output: Contribution to journalArticle

Abstract

Our improved understanding of the mechanisms of glomerular injury has allowed the design of novel therapeutic strategies to treat glomerulonephritis. While elimination of the etiologic factors continues to be a difficult task, modulation of the inflammatory response seems more promising at present. Several proinflammatory mediators have been identified as therapeutic targets and their inhibition has ameliorated glomerular injury in experimental animals. The role of anti-inflammatory molecules and the phenomenon of immunotolerance have gained particular attention and may prove to be useful therapeutically. Mediators of tissue repair have been found to contribute to glomerular destruction, and their inhibition was protective in a variety of experiments. In this review we discuss some of these novel approaches which may be targeted against human glomerulonephritis in the near future.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalJournal of Nephrology
Volume11
Issue number4
StatePublished - Jul 1998
Externally publishedYes

Keywords

  • Cytokines
  • G rowth factors
  • Glomerulonephritis
  • Leukotrienes
  • Lipoxygenase
  • Lymphocytes
  • Mechanisms
  • Treatment

ASJC Scopus subject areas

  • Nephrology

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  • Cite this

    Nassar, G. M., & Badr, K. F. (1998). Novel approaches to treatment of glomerulonephritis. Journal of Nephrology, 11(4), 177-184.