Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines

Emmanouil D. Karagiannis, Aleksander S. Popel

Research output: Contribution to journalArticle

Abstract

Angiogenesis is tightly regulated by numerous endogenous pro- and anti-angiogenic proteins and peptides. Among these are the CXC chemokines, a set of multifunctional peptides. CXC chemokines containing the ELR motif act as pro-angiogenic agents by regulating both endothelial cell proliferation and migration. Here we show that a set of six 22-24-amino acid peptides derived from the pro-angiogenic ELR-containing CXC chemokines exhibit notable anti-proliferative and anti-migratory activity in vitro; we call these peptides chemokinostatins. The ability of the identified peptides to inhibit the basic components of angiogenesis even though they are derived from pro-angiogenic proteins contributes towards the understanding of the diverse role of the CXC chemokine family in angiogenesis.

Original languageEnglish (US)
Pages (from-to)1356-1363
Number of pages8
JournalJournal of cellular biochemistry
Volume104
Issue number4
DOIs
StatePublished - Jul 1 2008

Keywords

  • Angiogenesis
  • Chemokinostatin
  • Endogenous
  • Endothelial cell
  • Inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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