Novel Angular Measures of Cervical Deformity Account for Upper Cervical Compensation and Sagittal Alignment

Themistocles S. Protopsaltis, Renaud Lafage, Shaleen Vira, Daniel Sciubba, Alex Soroceanu, Kojo Hamilton, Justin Smith, Peter G. Passias, Gregory Mundis, Robert Hart, Frank Schwab, Eric Klineberg, Christopher Shaffrey, Virginie Lafage, Christopher Ames

Research output: Contribution to journalArticle

Abstract

Study Design: This is a retrospective review of a prospective multicenter database. Objective: This study introduces 2 new cervical alignment measures accounting for both cervical deformity (CD) and upper cervical compensation. Summary of Background Data: Current descriptions of CD like the C2-C7 sagittal vertical axis (cSVA) do not account for compensatory mechanisms such as C0-C2 lordosis and pelvic tilt, which makes surgical planning difficult. The craniocervical angle (CCA) combines the slope of McGregor's line and the inclination from C7 to the hard palate. The C2-pelvic tilt (CPT) combines C2 tilt and pelvic tilt. Like the T1 pelvic angle, CPT is less affected by lower extremity and pelvic compensation. Methods: Novel and existing CD measures were correlated in 781 patients from a thoracolumbar deformity (TLD) database and 61 patients from a prospective CD database. CD patients were subanalyzed by region of deformity driver: Cervical or cervico-thoracic junction. TLD patients were substratified according to whether or not they had CD as well, where CD was defined as cSVA>4 cm or T1 slope minus cervical lordosis mismatch (TS-CL) >20. Results: TLD cohort: Mean cSVA was 31.7±17.8 mm. Subanalysis of TLD patients with CD versus no-CD demonstrated significant differences in CCA (56.2 vs. 60.6, P<0.001) and CPT (32.6 vs. 19.3, P<0.001). CCA and CPT correlated with cSVA (r=-0.488/r=0.418, P<0.001) and C0-C2 lordosis (r=-0.630/r=0.289,P<0.001). CD cohort: Mean cSVA was 47.3±32.2 mm. CCA and CPT correlated with cSVA (r=-0.811/r=0.657, P<0.001) and C0-C2 lordosis (r=-0.656/r=0.610, P<0.001). CD cohort subanalysis indicated that CT patients were significantly more deformed by cSVA (71.3 vs 24.0 mm, P<0.001), CCA (47.1 vs 59.1 degrees, P<0.001), and CPT (63.3 vs 43.8 degrees, P=0.002). Using linear regression analysis, cSVA of 4 cm corresponded to CCA of 53.2 degrees (r 2 =0.5) and CPT of 48.5 degrees (r 2 =0.4). Conclusions: CCA and CPT account for both cervical sagittal alignment and upper cervical compensation and can be utilized in assessment of cervical alignment.

Original languageEnglish (US)
Pages (from-to)E959-E967
JournalClinical Spine Surgery
Volume30
Issue number7
DOIs
StatePublished - 2017

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Lordosis
Databases
Hard Palate
Lower Extremity
Linear Models
Thorax
Regression Analysis

Keywords

  • HRQOL
  • Sagittal cervical deformity
  • upper cervical compensation

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Novel Angular Measures of Cervical Deformity Account for Upper Cervical Compensation and Sagittal Alignment. / Protopsaltis, Themistocles S.; Lafage, Renaud; Vira, Shaleen; Sciubba, Daniel; Soroceanu, Alex; Hamilton, Kojo; Smith, Justin; Passias, Peter G.; Mundis, Gregory; Hart, Robert; Schwab, Frank; Klineberg, Eric; Shaffrey, Christopher; Lafage, Virginie; Ames, Christopher.

In: Clinical Spine Surgery, Vol. 30, No. 7, 2017, p. E959-E967.

Research output: Contribution to journalArticle

Protopsaltis, TS, Lafage, R, Vira, S, Sciubba, D, Soroceanu, A, Hamilton, K, Smith, J, Passias, PG, Mundis, G, Hart, R, Schwab, F, Klineberg, E, Shaffrey, C, Lafage, V & Ames, C 2017, 'Novel Angular Measures of Cervical Deformity Account for Upper Cervical Compensation and Sagittal Alignment', Clinical Spine Surgery, vol. 30, no. 7, pp. E959-E967. https://doi.org/10.1097/BSD.0000000000000554
Protopsaltis, Themistocles S. ; Lafage, Renaud ; Vira, Shaleen ; Sciubba, Daniel ; Soroceanu, Alex ; Hamilton, Kojo ; Smith, Justin ; Passias, Peter G. ; Mundis, Gregory ; Hart, Robert ; Schwab, Frank ; Klineberg, Eric ; Shaffrey, Christopher ; Lafage, Virginie ; Ames, Christopher. / Novel Angular Measures of Cervical Deformity Account for Upper Cervical Compensation and Sagittal Alignment. In: Clinical Spine Surgery. 2017 ; Vol. 30, No. 7. pp. E959-E967.
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abstract = "Study Design: This is a retrospective review of a prospective multicenter database. Objective: This study introduces 2 new cervical alignment measures accounting for both cervical deformity (CD) and upper cervical compensation. Summary of Background Data: Current descriptions of CD like the C2-C7 sagittal vertical axis (cSVA) do not account for compensatory mechanisms such as C0-C2 lordosis and pelvic tilt, which makes surgical planning difficult. The craniocervical angle (CCA) combines the slope of McGregor's line and the inclination from C7 to the hard palate. The C2-pelvic tilt (CPT) combines C2 tilt and pelvic tilt. Like the T1 pelvic angle, CPT is less affected by lower extremity and pelvic compensation. Methods: Novel and existing CD measures were correlated in 781 patients from a thoracolumbar deformity (TLD) database and 61 patients from a prospective CD database. CD patients were subanalyzed by region of deformity driver: Cervical or cervico-thoracic junction. TLD patients were substratified according to whether or not they had CD as well, where CD was defined as cSVA>4 cm or T1 slope minus cervical lordosis mismatch (TS-CL) >20. Results: TLD cohort: Mean cSVA was 31.7±17.8 mm. Subanalysis of TLD patients with CD versus no-CD demonstrated significant differences in CCA (56.2 vs. 60.6, P<0.001) and CPT (32.6 vs. 19.3, P<0.001). CCA and CPT correlated with cSVA (r=-0.488/r=0.418, P<0.001) and C0-C2 lordosis (r=-0.630/r=0.289,P<0.001). CD cohort: Mean cSVA was 47.3±32.2 mm. CCA and CPT correlated with cSVA (r=-0.811/r=0.657, P<0.001) and C0-C2 lordosis (r=-0.656/r=0.610, P<0.001). CD cohort subanalysis indicated that CT patients were significantly more deformed by cSVA (71.3 vs 24.0 mm, P<0.001), CCA (47.1 vs 59.1 degrees, P<0.001), and CPT (63.3 vs 43.8 degrees, P=0.002). Using linear regression analysis, cSVA of 4 cm corresponded to CCA of 53.2 degrees (r 2 =0.5) and CPT of 48.5 degrees (r 2 =0.4). Conclusions: CCA and CPT account for both cervical sagittal alignment and upper cervical compensation and can be utilized in assessment of cervical alignment.",
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TY - JOUR

T1 - Novel Angular Measures of Cervical Deformity Account for Upper Cervical Compensation and Sagittal Alignment

AU - Protopsaltis, Themistocles S.

AU - Lafage, Renaud

AU - Vira, Shaleen

AU - Sciubba, Daniel

AU - Soroceanu, Alex

AU - Hamilton, Kojo

AU - Smith, Justin

AU - Passias, Peter G.

AU - Mundis, Gregory

AU - Hart, Robert

AU - Schwab, Frank

AU - Klineberg, Eric

AU - Shaffrey, Christopher

AU - Lafage, Virginie

AU - Ames, Christopher

PY - 2017

Y1 - 2017

N2 - Study Design: This is a retrospective review of a prospective multicenter database. Objective: This study introduces 2 new cervical alignment measures accounting for both cervical deformity (CD) and upper cervical compensation. Summary of Background Data: Current descriptions of CD like the C2-C7 sagittal vertical axis (cSVA) do not account for compensatory mechanisms such as C0-C2 lordosis and pelvic tilt, which makes surgical planning difficult. The craniocervical angle (CCA) combines the slope of McGregor's line and the inclination from C7 to the hard palate. The C2-pelvic tilt (CPT) combines C2 tilt and pelvic tilt. Like the T1 pelvic angle, CPT is less affected by lower extremity and pelvic compensation. Methods: Novel and existing CD measures were correlated in 781 patients from a thoracolumbar deformity (TLD) database and 61 patients from a prospective CD database. CD patients were subanalyzed by region of deformity driver: Cervical or cervico-thoracic junction. TLD patients were substratified according to whether or not they had CD as well, where CD was defined as cSVA>4 cm or T1 slope minus cervical lordosis mismatch (TS-CL) >20. Results: TLD cohort: Mean cSVA was 31.7±17.8 mm. Subanalysis of TLD patients with CD versus no-CD demonstrated significant differences in CCA (56.2 vs. 60.6, P<0.001) and CPT (32.6 vs. 19.3, P<0.001). CCA and CPT correlated with cSVA (r=-0.488/r=0.418, P<0.001) and C0-C2 lordosis (r=-0.630/r=0.289,P<0.001). CD cohort: Mean cSVA was 47.3±32.2 mm. CCA and CPT correlated with cSVA (r=-0.811/r=0.657, P<0.001) and C0-C2 lordosis (r=-0.656/r=0.610, P<0.001). CD cohort subanalysis indicated that CT patients were significantly more deformed by cSVA (71.3 vs 24.0 mm, P<0.001), CCA (47.1 vs 59.1 degrees, P<0.001), and CPT (63.3 vs 43.8 degrees, P=0.002). Using linear regression analysis, cSVA of 4 cm corresponded to CCA of 53.2 degrees (r 2 =0.5) and CPT of 48.5 degrees (r 2 =0.4). Conclusions: CCA and CPT account for both cervical sagittal alignment and upper cervical compensation and can be utilized in assessment of cervical alignment.

AB - Study Design: This is a retrospective review of a prospective multicenter database. Objective: This study introduces 2 new cervical alignment measures accounting for both cervical deformity (CD) and upper cervical compensation. Summary of Background Data: Current descriptions of CD like the C2-C7 sagittal vertical axis (cSVA) do not account for compensatory mechanisms such as C0-C2 lordosis and pelvic tilt, which makes surgical planning difficult. The craniocervical angle (CCA) combines the slope of McGregor's line and the inclination from C7 to the hard palate. The C2-pelvic tilt (CPT) combines C2 tilt and pelvic tilt. Like the T1 pelvic angle, CPT is less affected by lower extremity and pelvic compensation. Methods: Novel and existing CD measures were correlated in 781 patients from a thoracolumbar deformity (TLD) database and 61 patients from a prospective CD database. CD patients were subanalyzed by region of deformity driver: Cervical or cervico-thoracic junction. TLD patients were substratified according to whether or not they had CD as well, where CD was defined as cSVA>4 cm or T1 slope minus cervical lordosis mismatch (TS-CL) >20. Results: TLD cohort: Mean cSVA was 31.7±17.8 mm. Subanalysis of TLD patients with CD versus no-CD demonstrated significant differences in CCA (56.2 vs. 60.6, P<0.001) and CPT (32.6 vs. 19.3, P<0.001). CCA and CPT correlated with cSVA (r=-0.488/r=0.418, P<0.001) and C0-C2 lordosis (r=-0.630/r=0.289,P<0.001). CD cohort: Mean cSVA was 47.3±32.2 mm. CCA and CPT correlated with cSVA (r=-0.811/r=0.657, P<0.001) and C0-C2 lordosis (r=-0.656/r=0.610, P<0.001). CD cohort subanalysis indicated that CT patients were significantly more deformed by cSVA (71.3 vs 24.0 mm, P<0.001), CCA (47.1 vs 59.1 degrees, P<0.001), and CPT (63.3 vs 43.8 degrees, P=0.002). Using linear regression analysis, cSVA of 4 cm corresponded to CCA of 53.2 degrees (r 2 =0.5) and CPT of 48.5 degrees (r 2 =0.4). Conclusions: CCA and CPT account for both cervical sagittal alignment and upper cervical compensation and can be utilized in assessment of cervical alignment.

KW - HRQOL

KW - Sagittal cervical deformity

KW - upper cervical compensation

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