Novel adjunctive therapies for the treatment of tuberculosis

A. A. Ordonez, M. Maiga, S. Gupta, E. A. Weinstein, W. R. Bishai, S. K. Jain

Research output: Contribution to journalReview article

Abstract

Despite significant efforts to control tuberculosis (TB), the disease remains a major global threat, with an estimated 8.6 million new cases and 1.3 million deaths in 2012 alone. Significant treatment challenges include HIV co-infection, the dramatic rise of multidrug-resistant TB and the vast reservoir of latently infected individuals, who will develop active disease years after the initial infection. The long duration of chemotherapy also remains a major barrier to effective large scale treatment of TB. Significant advances are being made in the development of shorter and effective TB drug regimens and there is growing evidence that host-directed and "non-antimicrobial" pathogen-directed therapies, could serve as novel approaches to enhance TB treatments. This review highlights the rationale for using these therapies and summarizes some of the progress in this field.

Original languageEnglish (US)
Pages (from-to)385-395
Number of pages11
JournalCurrent Molecular Medicine
Volume14
Issue number3
DOIs
StatePublished - Jan 1 2014

Keywords

  • Corticosteroids
  • Efflux pump inhibitors
  • Inflammation
  • Microenvironment
  • TNF-α

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

Fingerprint Dive into the research topics of 'Novel adjunctive therapies for the treatment of tuberculosis'. Together they form a unique fingerprint.

  • Cite this