Abstract
Prepared from a commercial prostaglandin building block, novel vitamin D3 analogs with a contracted five-membered A-ring were designed and synthesized to mimic the A-ring diol structure of the natural hormone 1α,25-dihydroxyvitamin D3. Prepared from commercial 1,4-cyclohexanedione, a structurally simplified analog was designed and synthesized in which a suitably oriented primary allylic hydroxyl group at the C-2 position might be a surrogate for the biologically important 1α-OH in the natural hormone.
Original language | English (US) |
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Pages (from-to) | 2959-2966 |
Number of pages | 8 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 13 |
Issue number | 8 |
DOIs | |
State | Published - Apr 15 2005 |
Keywords
- Growth inhibition
- SAR
- Vitamin D analogs
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry