Not “doing the same thing over and over again”

Research output: Contribution to journalEditorialpeer-review


Intracerebral hemorrhage (ICH) with intraventricular extension is a devastating disease occurring in 40% of patients with spontaneous ICH. Although the CLEAR III trial (NCT00784134) demonstrated mortality reduction with intraventricular alteplase (versus saline), lessons learned warrant a therapeutic trial focusing on disease severity and treatment endpoints that support a high likelihood of improvement. We must answer questions of maximizing therapy intensity in large intraventricular hemorrhage (IVH) to promote good neurologic outcomes if we are committed to treating ICH and the full spectrum of stroke severity.

Original languageEnglish (US)
Pages (from-to)29-30
Number of pages2
JournalEuropean Neurological Review
Issue number1
StatePublished - Mar 1 2018


  • Alteplase
  • Extra-ventricular drain (EVD)
  • Intracerebral hemorrhage (ICH)
  • Intraventricular hemorrhage (IVH)
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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