TY - JOUR
T1 - North American Fetal Therapy Network
T2 - Intervention vs expectant management for stage I twin-twin transfusion syndrome
AU - Emery, Stephen P.
AU - Hasley, Steve K.
AU - Catov, Janet M.
AU - Miller, Russell S.
AU - Moon-Grady, Anita J.
AU - Baschat, Ahmet
AU - Johnson, Anthony
AU - Lim, Foong Yen
AU - Gagnon, Alain L.
AU - O'Shaughnessy, Richard W.
AU - Ozcan, Tulin
AU - Luks, Francois I.
PY - 2015/12/12
Y1 - 2015/12/12
N2 - Background: Stage I twin-twin transfusion syndrome presents a management dilemma. Intervention may lead to procedure-related complications while expectant management risks deterioration. Insufficient data exist to inform decision-making. Objective: The aim of this retrospective observational study was to describe the natural history of stage I twin-twin transfusion syndrome, to assess for predictors of disease behavior, and to compare pregnancy outcomes after intervention at stage I vs expectant management. Study Design: Ten North American Fetal Therapy Network centers submitted well-documented cases of stage I twin-twin transfusion syndrome for analysis. Cases were retrospectively divided into 3 management strategies: those managed expectantly, those who underwent amnioreduction at stage I, and those who underwent laser therapy at stage I. Outcomes were categorized as no survivors, 1 survivor, 2 survivors, or at least 1 survivor to live birth, and good (twin live birth ≥30.0 weeks), mixed (single fetal demise or delivery between 26.0-29.9 weeks), and poor (double fetal demise or delivery
AB - Background: Stage I twin-twin transfusion syndrome presents a management dilemma. Intervention may lead to procedure-related complications while expectant management risks deterioration. Insufficient data exist to inform decision-making. Objective: The aim of this retrospective observational study was to describe the natural history of stage I twin-twin transfusion syndrome, to assess for predictors of disease behavior, and to compare pregnancy outcomes after intervention at stage I vs expectant management. Study Design: Ten North American Fetal Therapy Network centers submitted well-documented cases of stage I twin-twin transfusion syndrome for analysis. Cases were retrospectively divided into 3 management strategies: those managed expectantly, those who underwent amnioreduction at stage I, and those who underwent laser therapy at stage I. Outcomes were categorized as no survivors, 1 survivor, 2 survivors, or at least 1 survivor to live birth, and good (twin live birth ≥30.0 weeks), mixed (single fetal demise or delivery between 26.0-29.9 weeks), and poor (double fetal demise or delivery
KW - Expectant management
KW - Natural history
KW - Quintero stage I
KW - Treatment
KW - Twin-twin transfusion syndrome
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U2 - 10.1016/j.ajog.2016.04.024
DO - 10.1016/j.ajog.2016.04.024
M3 - Article
C2 - 27131587
AN - SCOPUS:84973567151
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
ER -