Normothermic orthotopic canine heart homotransplantation

J. D. Whiffen, W. C. Boake, Vincent L Gott

Research output: Contribution to journalArticle

Abstract

A technique for normothermic orthotopic heart transplantation in the adult dog is described in detail. A brief review of the results of the first twenty transplantations performed during the development of the technique is presented. Only once did the transplanted heart fail to perfuse the recipient. One animal survived for 11 days. The known causes of death in hearts transplanted by this technique are discussed. Sudden death due to unknown causes occurred in several animals after twelve hours to 2 1 2 days of excellent homograft heart function. The determination of the exact cause of death of this group of animals will most likely have to await the development of new knowledge of the biochemical behavior of homografted hearts.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalJournal of Surgical Research
Volume7
Issue number9
StatePublished - Sep 1967

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Canidae
Cause of Death
Heart Transplantation
Sudden Death
Allografts
Transplantation
Dogs

ASJC Scopus subject areas

  • Surgery

Cite this

Normothermic orthotopic canine heart homotransplantation. / Whiffen, J. D.; Boake, W. C.; Gott, Vincent L.

In: Journal of Surgical Research, Vol. 7, No. 9, 09.1967, p. 421-426.

Research output: Contribution to journalArticle

Whiffen, J. D. ; Boake, W. C. ; Gott, Vincent L. / Normothermic orthotopic canine heart homotransplantation. In: Journal of Surgical Research. 1967 ; Vol. 7, No. 9. pp. 421-426.
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