NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps

Guanshu Liu, Kannie W Y Chan, Xiaolei Song, Jiangyang Zhang, Assaf A. Gilad, Jeff W Bulte, Peter C Van Zijl, Michael T Mcmahon

Research output: Contribution to journalArticle

Abstract

An MRI segmentation technique based on collecting two additional saturation transfer images is proposed as an aid for improved detection of chemical exchange saturation transfer agents. In this approach, the additional images are acquired at saturation frequencies of -12.5 and -50 ppm. Use of the ratio of these images allows differentiation of voxels with low magnetization transfer contrast (such as fat, cerebrospinal fluid, edema, or blood) from target tissue voxels using a global threshold determined by histogram analysis. We demonstrate that this technique can reduce artifacts, in vitro, in a phantom containing tubes with chemical exchange saturation transfer contrast agent embedded in either crosslinked bovine serum albumin or buffer, and in vivo for detecting diamagnetic CEST (DIACEST) liposomes injected into mice. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)516-523
Number of pages8
JournalMagnetic Resonance in Medicine
Volume69
Issue number2
DOIs
StatePublished - Feb 2013

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Bovine Serum Albumin
Liposomes
Artifacts
Contrast Media
Cerebrospinal Fluid
Edema
Buffers
Fats
In Vitro Techniques

Keywords

  • chemical exchange saturation transfer (CEST)
  • magnetization transfer (MT)
  • MRI segmentation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps. / Liu, Guanshu; Chan, Kannie W Y; Song, Xiaolei; Zhang, Jiangyang; Gilad, Assaf A.; Bulte, Jeff W; Van Zijl, Peter C; Mcmahon, Michael T.

In: Magnetic Resonance in Medicine, Vol. 69, No. 2, 02.2013, p. 516-523.

Research output: Contribution to journalArticle

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