Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO2

Dengrong Jiang, Zixuan Lin, Peiying Liu, Sandeepa Sur, Cuimei Xu, Kaisha Hazel, George Pottanat, Sevil Yasar, Paul Rosenberg, Marilyn Albert, Hanzhang Lu

Research output: Contribution to journalArticle

Abstract

Cerebral oxygen extraction fraction is an important physiological index of the brain’s oxygen consumption and supply and has been suggested to be a potential biomarker for a number of diseases such as stroke, Alzheimer’s disease, multiple sclerosis, sickle cell disease, and metabolic disorders. However, in order for oxygen extraction fraction to be a sensitive biomarker for personalized disease diagnosis, inter-subject variations in normal subjects must be minimized or accounted for, which will otherwise obscure its interpretation. Therefore, it is essential to investigate the physiological underpinnings of normal differences in oxygen extraction fraction. This work used two studies, one discovery study and one verification study, to examine the extent to which an individual’s end-tidal CO2 can explain variations in oxygen extraction fraction. It was found that, across normal subjects, oxygen extraction fraction is inversely correlated with end-tidal CO2. Approximately 50% of the inter-subject variations in oxygen extraction fraction can be attributed to end-tidal CO2 differences. In addition, oxygen extraction fraction was found to be positively associated with age and systolic blood pressure. By accounting for end-tidal CO2, age, and systolic blood pressure of the subjects, normal variations in oxygen extraction fraction can be reduced by 73%, which is expected to substantially enhance the utility of oxygen extraction fraction as a disease biomarker.

Original languageEnglish (US)
JournalJournal of Cerebral Blood Flow and Metabolism
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Oxygen
Brain
Blood Pressure
Biomarkers
Sickle Cell Anemia
Oxygen Consumption
Multiple Sclerosis
Alzheimer Disease
Stroke

Keywords

  • end-tidal CO
  • Oxygen extraction fraction
  • T-Relaxation-Under-Spin-Tagging
  • variation
  • venous oxygenation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO2. / Jiang, Dengrong; Lin, Zixuan; Liu, Peiying; Sur, Sandeepa; Xu, Cuimei; Hazel, Kaisha; Pottanat, George; Yasar, Sevil; Rosenberg, Paul; Albert, Marilyn; Lu, Hanzhang.

In: Journal of Cerebral Blood Flow and Metabolism, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Xu, Cuimei

AU - Hazel, Kaisha

AU - Pottanat, George

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AU - Rosenberg, Paul

AU - Albert, Marilyn

AU - Lu, Hanzhang

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