Normal polymorphism in the incomplete trinucleotide repeat of the arginine-rich protein gene

Ella Evron, Paul Cairns, Naomi Halachmi, Steven A. Ahrendt, Andre L. Reed, David Sidransky

Research output: Contribution to journalArticle

Abstract

The arginine-rich protein (ARP) gene was recently cloned and localized to human chromosome band 3p21. Recent reports have suggested that ARP is mutated in a high percentage of different human tumors. We amplified and sequenced the multiple arginine coding area of the ARP gene in primary head and neck, non-small cell lung, and renal cell cancers. We found a high frequency of genetic changes in this region, including a single base pair substitution and deletions of arginine repeats in primary tumors. However, these changes were always present in matched normal controls. Thus, the variations in the ARP trinucleotide repeat region represent normal polymorphisms rather than tumor-specific mutations.

Original languageEnglish (US)
Pages (from-to)2888-2889
Number of pages2
JournalCancer Research
Volume57
Issue number14
StatePublished - Jul 15 1997

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Evron, E., Cairns, P., Halachmi, N., Ahrendt, S. A., Reed, A. L., & Sidransky, D. (1997). Normal polymorphism in the incomplete trinucleotide repeat of the arginine-rich protein gene. Cancer Research, 57(14), 2888-2889.