Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: The Handan Eye Study

Xin Rong Duan, Yuan Bo Liang, David S Friedman, Lan Ping Sun, Tien Yin Wong, Qiu Shan Tao, Lingzhi Bao, Ning Li Wang, Jie Jin Wang

Research output: Contribution to journalArticle

Abstract

Purpose: To describe macular thickness measured by optical coherence tomography (OCT) in healthy eyes of adult Chinese persons. Design: Population-based cross-sectional study. Participants: Chinese adults aged 30+ years who were residents of Handan, North China. Methods: The Handan Eye Study is a population-based study of eye disease in Chinese persons. Eligible residents underwent a comprehensive ophthalmic examination including OCT (Stratus OCT, Carl Zeiss Meditec Inc., Jena, Germany). Fast macular thickness scans were performed over maculae within 6 mm in diameter, divided into 3 regions (central, inner, and outer, with a diameter of 1, 3, and 6 mm, respectively) and 9 quadrants (1 in the central region and 4 each in the inner and outer regions). Retinal thickness (means and standard deviations) was calculated by OCT mapping software, presented for foveal minimum, central macula (within 1 mm diameter), and inner and outer regions divided by 8 quadrants. Main Outcome Measures: Macular thickness measured by OCT. Results: Of the 6830 participants (90.4% response rate) examined, 2230 eyes of healthy subjects with high-quality OCT scans were selected (32.7% of participants; mean age, 46.4±9.9 years, 58.4% were women). The mean foveal minimum, central, inner, and outer macular thicknesses were 150.3 (18.1) μm, 176.4 (17.5) μm, 255.3 (14.9) μm, and 237.7 (12.4) μm, respectively (overall differences, P3, and the mean total macular volume was 6.761 (0.516) mm 3. In the inner region, the nasal quadrant was thinner than the superior and inferior quadrants, and in the outer region, the nasal quadrant was the thickest (P

Original languageEnglish (US)
Pages (from-to)1585-1594
Number of pages10
JournalOphthalmology
Volume117
Issue number8
DOIs
StatePublished - 2010

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Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons : The Handan Eye Study. / Duan, Xin Rong; Liang, Yuan Bo; Friedman, David S; Sun, Lan Ping; Wong, Tien Yin; Tao, Qiu Shan; Bao, Lingzhi; Wang, Ning Li; Wang, Jie Jin.

In: Ophthalmology, Vol. 117, No. 8, 2010, p. 1585-1594.

Research output: Contribution to journalArticle

Duan, Xin Rong ; Liang, Yuan Bo ; Friedman, David S ; Sun, Lan Ping ; Wong, Tien Yin ; Tao, Qiu Shan ; Bao, Lingzhi ; Wang, Ning Li ; Wang, Jie Jin. / Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons : The Handan Eye Study. In: Ophthalmology. 2010 ; Vol. 117, No. 8. pp. 1585-1594.
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title = "Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: The Handan Eye Study",
abstract = "Purpose: To describe macular thickness measured by optical coherence tomography (OCT) in healthy eyes of adult Chinese persons. Design: Population-based cross-sectional study. Participants: Chinese adults aged 30+ years who were residents of Handan, North China. Methods: The Handan Eye Study is a population-based study of eye disease in Chinese persons. Eligible residents underwent a comprehensive ophthalmic examination including OCT (Stratus OCT, Carl Zeiss Meditec Inc., Jena, Germany). Fast macular thickness scans were performed over maculae within 6 mm in diameter, divided into 3 regions (central, inner, and outer, with a diameter of 1, 3, and 6 mm, respectively) and 9 quadrants (1 in the central region and 4 each in the inner and outer regions). Retinal thickness (means and standard deviations) was calculated by OCT mapping software, presented for foveal minimum, central macula (within 1 mm diameter), and inner and outer regions divided by 8 quadrants. Main Outcome Measures: Macular thickness measured by OCT. Results: Of the 6830 participants (90.4{\%} response rate) examined, 2230 eyes of healthy subjects with high-quality OCT scans were selected (32.7{\%} of participants; mean age, 46.4±9.9 years, 58.4{\%} were women). The mean foveal minimum, central, inner, and outer macular thicknesses were 150.3 (18.1) μm, 176.4 (17.5) μm, 255.3 (14.9) μm, and 237.7 (12.4) μm, respectively (overall differences, P3, and the mean total macular volume was 6.761 (0.516) mm 3. In the inner region, the nasal quadrant was thinner than the superior and inferior quadrants, and in the outer region, the nasal quadrant was the thickest (P",
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AU - Wong, Tien Yin

AU - Tao, Qiu Shan

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AU - Wang, Ning Li

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