Normal human plasma contains antibodies that specifically block neuropathy-associated human anti-GM1 IgG-antibodies

Pablo H.H. Lopez, Fernando J. Irazoqui, Gustavo A. Nores

Research output: Contribution to journalArticlepeer-review

Abstract

Intravenous immunoglobulin (IVIg) is used in the treatment of a variety of autoimmune diseases. The blocking of disease-associated antibodies by anti-idiotype antibodies present in IVIg has been proposed as an action mechanism. Anti-GM1 antibodies have been implicated in motor neuropathies. Although IVIg is frequently applied for these diseases, the presence in IVIg or in human plasma of anti-idiotype antibodies that recognize anti-GM1 antibodies has not been clearly demonstrated. Here we present evidence that normal human plasma contains antibodies that inhibit the binding of anti-GM1 IgG-antibodies from neuropathy patients but do not inhibit anti-GM1 IgG-antibodies of rabbit origin with the same fine specificity. The significance of these findings in the course of acute and chronic neuropathies is discussed. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalJournal of Neuroimmunology
Volume105
Issue number2
DOIs
StatePublished - Jun 26 2000
Externally publishedYes

Keywords

  • Anti-GM1 antibodies
  • Anti-idiotype antibodies
  • GM1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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