Abstract
Recent studies of normal and neoplastic lymphocytes have revealed overlapping metabolic rewiring in activated T cells and Myc-transformed lymphocytes. Myc expression is attenuated in normal lymphocytes that return to the basal state, but Notch-activated or Myc-transformed lymphocytes persistently express Myc, which activates genes involved in glucose and glutamine metabolism. Although this difference could provide a therapeutic window for the treatment of cancers, the overlapping metabolic profiles suggest a potential for immunosuppression by metabolic inhibitors. Recent studies of normal and neoplastic lymphocytes reveal overlapping metabolic rewiring in activated T cells and Myc-transformed lymphocytes. Myc expression is eventually attenuated in normal lymphocytes but maintained in transformed lymphocytes,activating genes involved in glucose and glutamine metabolism. While this difference could provide a therapeutic window to treat cancers, the overlapping metabolic profiles suggest potential immune-suppression by metabolic inhibitors
Original language | English (US) |
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Pages (from-to) | 2598-2609 |
Number of pages | 12 |
Journal | FEBS Journal |
Volume | 279 |
Issue number | 15 |
DOIs | |
State | Published - Aug 2012 |
Externally published | Yes |
Keywords
- cancer
- leukemia
- lymphocytes
- lymphoma
- metabolism
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
- Cell Biology