Normal and cancer cell metabolism: Lymphocytes and lymphoma

Brian J. Altman, Chi V. Dang

Research output: Contribution to journalArticle

Abstract

Recent studies of normal and neoplastic lymphocytes have revealed overlapping metabolic rewiring in activated T cells and Myc-transformed lymphocytes. Myc expression is attenuated in normal lymphocytes that return to the basal state, but Notch-activated or Myc-transformed lymphocytes persistently express Myc, which activates genes involved in glucose and glutamine metabolism. Although this difference could provide a therapeutic window for the treatment of cancers, the overlapping metabolic profiles suggest a potential for immunosuppression by metabolic inhibitors. Recent studies of normal and neoplastic lymphocytes reveal overlapping metabolic rewiring in activated T cells and Myc-transformed lymphocytes. Myc expression is eventually attenuated in normal lymphocytes but maintained in transformed lymphocytes,activating genes involved in glucose and glutamine metabolism. While this difference could provide a therapeutic window to treat cancers, the overlapping metabolic profiles suggest potential immune-suppression by metabolic inhibitors

Original languageEnglish (US)
Pages (from-to)2598-2609
Number of pages12
JournalFEBS Journal
Volume279
Issue number15
DOIs
StatePublished - Aug 2012
Externally publishedYes

Keywords

  • cancer
  • leukemia
  • lymphocytes
  • lymphoma
  • metabolism

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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