TY - JOUR
T1 - NO/redox disequilibrium in the failing heart and cardiovascular system
AU - Hare, Joshua M.
AU - Stamler, Jonathan S.
PY - 2005/3
Y1 - 2005/3
N2 - There is growing evidence that the altered production and/or spatiotemporal distribution of reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels in terms of adverse effects on signaling elements in the heart, vasculature, and blood that subserve cardiac and vascular homeostasis.
AB - There is growing evidence that the altered production and/or spatiotemporal distribution of reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels in terms of adverse effects on signaling elements in the heart, vasculature, and blood that subserve cardiac and vascular homeostasis.
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U2 - 10.1172/JCI200524459
DO - 10.1172/JCI200524459
M3 - Article
C2 - 15765132
AN - SCOPUS:14644423890
SN - 0021-9738
VL - 115
SP - 509
EP - 517
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 3
ER -