Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease

Cynthia A. Jengeleski, Richard E. Powers, Daniel T. O'Connor, Donald L. Price

Research output: Contribution to journalArticlepeer-review

Abstract

Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalBrain research
Volume481
Issue number2
DOIs
StatePublished - Mar 6 1989

Keywords

  • Dopamine β-hydroxylase
  • Immunocytochemistry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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