Abstract
Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 378-382 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 481 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 6 1989 |
Fingerprint
Keywords
- Dopamine β-hydroxylase
- Immunocytochemistry
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Noradrenergic innervation of human pineal gland : abnormalities in aging and Alzheimer's disease. / Jengeleski, Cynthia A.; Powers, Richard E.; O'Connor, Daniel T.; Price, Donald L.
In: Brain Research, Vol. 481, No. 2, 06.03.1989, p. 378-382.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noradrenergic innervation of human pineal gland
T2 - abnormalities in aging and Alzheimer's disease
AU - Jengeleski, Cynthia A.
AU - Powers, Richard E.
AU - O'Connor, Daniel T.
AU - Price, Donald L.
PY - 1989/3/6
Y1 - 1989/3/6
N2 - Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.
AB - Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.
KW - Dopamine β-hydroxylase
KW - Immunocytochemistry
UR - http://www.scopus.com/inward/record.url?scp=0024512226&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024512226&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(89)90818-4
DO - 10.1016/0006-8993(89)90818-4
M3 - Article
C2 - 2720390
AN - SCOPUS:0024512226
VL - 481
SP - 378
EP - 382
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -