Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease

Cynthia A. Jengeleski; Richard E. Powers; Daniel T. O'Connor; Donald L. Price

doi:10.1016/0006-8993(89)90818-4

Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease

Cynthia A. Jengeleski, Richard E. Powers, Daniel T. O'Connor, Donald L. Price

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.

Original language	English (US)
Pages (from-to)	378-382
Number of pages	5
Journal	Brain research
Volume	481
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(89)90818-4
State	Published - Mar 6 1989

Keywords

Dopamine β-hydroxylase
Immunocytochemistry

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)90818-4

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abstract = "Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.",

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AU - Jengeleski, Cynthia A.

AU - Powers, Richard E.

AU - O'Connor, Daniel T.

AU - Price, Donald L.

PY - 1989/3/6

Y1 - 1989/3/6

N2 - Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.

AB - Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.

KW - Dopamine β-hydroxylase

KW - Immunocytochemistry

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Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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