Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease

Cynthia A. Jengeleski, Richard E. Powers, Daniel T. O'Connor, Donald L. Price

Research output: Contribution to journalArticle

Abstract

Using previously characterized polyclonal antibody directed against dopamine β-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalBrain Research
Volume481
Issue number2
DOIs
StatePublished - Mar 6 1989

Fingerprint

Pineal Gland
Alzheimer Disease
Axons
Superior Cervical Ganglion
Mixed Function Oxygenases
Dopamine
Pathology
Antibodies

Keywords

  • Dopamine β-hydroxylase
  • Immunocytochemistry

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Noradrenergic innervation of human pineal gland : abnormalities in aging and Alzheimer's disease. / Jengeleski, Cynthia A.; Powers, Richard E.; O'Connor, Daniel T.; Price, Donald L.

In: Brain Research, Vol. 481, No. 2, 06.03.1989, p. 378-382.

Research output: Contribution to journalArticle

Jengeleski, Cynthia A. ; Powers, Richard E. ; O'Connor, Daniel T. ; Price, Donald L. / Noradrenergic innervation of human pineal gland : abnormalities in aging and Alzheimer's disease. In: Brain Research. 1989 ; Vol. 481, No. 2. pp. 378-382.
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