TY - JOUR
T1 - Nontransient silk sandwich for soft, conformal bionic links
AU - Patil, Anoop C.
AU - Bandla, Aishwarya
AU - Liu, Yu Hang
AU - Luo, Baiwen
AU - Thakor, Nitish V.
N1 - Funding Information:
The work is supported by National Research Foundation (NRF-CRP10-2012-01). We thank Marshal Dian Sheng Wong and Li Jing Ong, Singapore Institute for Neurotechnology for their excellent technical assistance with setting up the recording apparatus; Gil G. L. Gammad, Singapore Institute for Neurotechnology for his excellent assistance with animal handling and surgery; Dr. Dihan Hasan (Group of Chengkuo Lee, Department of Electrical & Computer Engineering, NUS) for his inputs and excellent support during the Raman spectroscopy studies; and Prof. Yen Shih-Cheng and Prof. Chengkuo Lee (Singapore Institute for Neurotechnology and Department of Electrical & Computer Engineering, NUS) for their inputs during the design and fabrication of silk sensors and excellent support during the animal experiments.
Funding Information:
The work is supported by National Research Foundation ( NRF-CRP10-2012-01 ). We thank Marshal Dian Sheng Wong and Li Jing Ong, Singapore Institute for Neurotechnology for their excellent technical assistance with setting up the recording apparatus; Gil G. L. Gammad, Singapore Institute for Neurotechnology for his excellent assistance with animal handling and surgery; Dr. Dihan Hasan (Group of Chengkuo Lee, Department of Electrical & Computer Engineering, NUS) for his inputs and excellent support during the Raman spectroscopy studies; and Prof. Yen Shih-Cheng and Prof. Chengkuo Lee (Singapore Institute for Neurotechnology and Department of Electrical & Computer Engineering, NUS) for their inputs during the design and fabrication of silk sensors and excellent support during the animal experiments.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Soft biointerfaces that maintain intimate contact with the smooth but curved tissue and organ surfaces are critical for providing reliable readouts of in vivo electrical activity. In contrast to conventional biodegradable class of silk scaffolds, we report for the first time, nontransient, or sustainable and implantable silk fibroin bionic interfaces for direct electrical recording of a variety of biopotentials such as neural activity from the peripheral nerves and the cortex. This new class of soft and flexible interfaces are enabled by a silk fibroin-based strategy that relies on substrates and superstrates of nontransient water-stable silk for supporting the electrode constructs. We present SILK-SEAL that involves soft assembly of thin silk layers resulting in a silk sandwich, and QUICK-SILK, an elastomer-silk bandage backing enabling fully functional silk electrode sensors that can be securely deployed in vivo. The resulting novel thin film devices achieve biopotential recording from the peripheral nerve and the cortex in a rodent model, thanks to the thin form factor of the silk film appliqués that enable conformal lamination on the target tissue surfaces, and the adhesive elastomer-silk backing, a suture-free approach that assists in pasting and securing the arrays in place. The neural recording experiments demonstrate a novel mode of use for the silk sensors as non-dissolvable biointerfaces, providing evidence for their application in preclinical research studies. The silk interfaces reported here, serve as the first significant leap towards non-dissolvable silk bioelectronics for in vivo use.
AB - Soft biointerfaces that maintain intimate contact with the smooth but curved tissue and organ surfaces are critical for providing reliable readouts of in vivo electrical activity. In contrast to conventional biodegradable class of silk scaffolds, we report for the first time, nontransient, or sustainable and implantable silk fibroin bionic interfaces for direct electrical recording of a variety of biopotentials such as neural activity from the peripheral nerves and the cortex. This new class of soft and flexible interfaces are enabled by a silk fibroin-based strategy that relies on substrates and superstrates of nontransient water-stable silk for supporting the electrode constructs. We present SILK-SEAL that involves soft assembly of thin silk layers resulting in a silk sandwich, and QUICK-SILK, an elastomer-silk bandage backing enabling fully functional silk electrode sensors that can be securely deployed in vivo. The resulting novel thin film devices achieve biopotential recording from the peripheral nerve and the cortex in a rodent model, thanks to the thin form factor of the silk film appliqués that enable conformal lamination on the target tissue surfaces, and the adhesive elastomer-silk backing, a suture-free approach that assists in pasting and securing the arrays in place. The neural recording experiments demonstrate a novel mode of use for the silk sensors as non-dissolvable biointerfaces, providing evidence for their application in preclinical research studies. The silk interfaces reported here, serve as the first significant leap towards non-dissolvable silk bioelectronics for in vivo use.
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U2 - 10.1016/j.mattod.2019.08.007
DO - 10.1016/j.mattod.2019.08.007
M3 - Article
AN - SCOPUS:85072806267
VL - 32
SP - 68
EP - 83
JO - Materials Today
JF - Materials Today
SN - 1369-7021
ER -