TY - JOUR
T1 - Nonsurgical strategies in patients with net liver metastases
T2 - A protocol of four systematic reviews
AU - Limani, Perparim
AU - Tschuor, Christoph
AU - Gort, Laura
AU - Balmer, Bettina
AU - Gu, Alexander
AU - Ceresa, Christos
AU - Raptis, Dimitri Aristotle
AU - Lesurtel, Mickael
AU - Puhan, Milo
AU - Breitenstein, Stefan
PY - 2014
Y1 - 2014
N2 - Background: Patients diagnosed with neuroendocrine tumors (NETs) with hepatic metastases generally have a worse prognosis as compared with patients with nonmetastasized NETs. Due to tumor location and distant metastases, a surgical approach is often not possible and nonsurgical therapeutic strategies may apply. Objective: The aim of these systematic reviews is to evaluate the role of nonsurgical therapy options for patients with nonresectable liver metastases of NETs. Methods: An objective group of librarians will provide an electronic search strategy to examine the MEDLINE, EMBASE, and The Cochrane Library (Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials [CENTRAL]) databases. There will be no restriction concerning language and publication date. The qualitative and quantitative synthesis of the systematic review will be conducted with randomized controlled trials (RCT), prospective, and retrospective comparative cohort, and case-control studies. Case series will be collected in a separate database and only used for descriptive purposes. Results: This study is ongoing and presents a protocol of four systematic reviews to assess the role of nonsurgical treatment options in patients with neuroendocrine liver metastases. Conclusions: These systematic reviews, performed according to this protocol, will assess the value of noninvasive therapy options for patients with nonresectable liver metastases of NETs in combination with invasive techniques, such as percutaneous liver-directed techniques and local ablation techniques.
AB - Background: Patients diagnosed with neuroendocrine tumors (NETs) with hepatic metastases generally have a worse prognosis as compared with patients with nonmetastasized NETs. Due to tumor location and distant metastases, a surgical approach is often not possible and nonsurgical therapeutic strategies may apply. Objective: The aim of these systematic reviews is to evaluate the role of nonsurgical therapy options for patients with nonresectable liver metastases of NETs. Methods: An objective group of librarians will provide an electronic search strategy to examine the MEDLINE, EMBASE, and The Cochrane Library (Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials [CENTRAL]) databases. There will be no restriction concerning language and publication date. The qualitative and quantitative synthesis of the systematic review will be conducted with randomized controlled trials (RCT), prospective, and retrospective comparative cohort, and case-control studies. Case series will be collected in a separate database and only used for descriptive purposes. Results: This study is ongoing and presents a protocol of four systematic reviews to assess the role of nonsurgical treatment options in patients with neuroendocrine liver metastases. Conclusions: These systematic reviews, performed according to this protocol, will assess the value of noninvasive therapy options for patients with nonresectable liver metastases of NETs in combination with invasive techniques, such as percutaneous liver-directed techniques and local ablation techniques.
KW - Adjuvant
KW - Liver resection
KW - Liver transplantation
KW - Neoadjuvant
KW - NET
KW - Neuroendocrine tumor
KW - Primary NET
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=84897445310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897445310&partnerID=8YFLogxK
U2 - 10.2196/resprot.2893
DO - 10.2196/resprot.2893
M3 - Article
C2 - 24610518
AN - SCOPUS:84897445310
SN - 1438-8871
VL - 16
JO - Journal of Medical Internet Research
JF - Journal of Medical Internet Research
IS - 3
ER -