Nonsteroidal anti-inflammatory drugs in alzheimer's disease

J. B. Rich, D. X. Rasmusson, M. F. Folstein, K. A. Carson, C. Kawas, J. Brandt

Research output: Contribution to journalArticle

Abstract

Article abstract-We reviewed the records of 210 patients in the Johns Hopkins Alzheimer's Disease Research Center to evaluate the role of nonsteroidal anti-inflammatory drugs (NSAIDs) on clinical features and progression of the disease. We compared patients taking NSAIDs or aspirin on a daily basis (N = 32) to non-NSAID patients (N = 177) on clinical, cognitive, and psychiatric measures. The NSAID group had a significantly shorter duration of illness at study entry. Even after controlling for this difference, the NSAID group performed better on the Mini-Mental State Examination, Boston Naming Test, and the delayed condition of the Benton Visual Retention Test. Furthermore, analysis of longitudinal changes over 1 year revealed less decline among NSAID patients than among non-NSAID patients on measures of verbal fluency, spatial recognition, and orientation. These findings support other recent studies suggesting that NSAIDs may serve a protective role in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalNeurology
Volume45
Issue number1
DOIs
StatePublished - Jan 1995

ASJC Scopus subject areas

  • Clinical Neurology

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