Nonsteroidal anti-inflammatory drugs in alzheimer's disease

J. B. Rich, D. X. Rasmusson, Marshal F. Folstein, Kathryn Anne Carson, C. Kawas, Jason Brandt

Research output: Contribution to journalArticle

Abstract

Article abstract-We reviewed the records of 210 patients in the Johns Hopkins Alzheimer's Disease Research Center to evaluate the role of nonsteroidal anti-inflammatory drugs (NSAIDs) on clinical features and progression of the disease. We compared patients taking NSAIDs or aspirin on a daily basis (N = 32) to non-NSAID patients (N = 177) on clinical, cognitive, and psychiatric measures. The NSAID group had a significantly shorter duration of illness at study entry. Even after controlling for this difference, the NSAID group performed better on the Mini-Mental State Examination, Boston Naming Test, and the delayed condition of the Benton Visual Retention Test. Furthermore, analysis of longitudinal changes over 1 year revealed less decline among NSAID patients than among non-NSAID patients on measures of verbal fluency, spatial recognition, and orientation. These findings support other recent studies suggesting that NSAIDs may serve a protective role in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalNeurology
Volume45
Issue number1
StatePublished - 1995

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Alzheimer Disease
Anti-Inflammatory Agents
Pharmaceutical Preparations
Alzheimer's Disease
Drugs
Aspirin
Psychiatry
Disease Progression
Research

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Nonsteroidal anti-inflammatory drugs in alzheimer's disease. / Rich, J. B.; Rasmusson, D. X.; Folstein, Marshal F.; Carson, Kathryn Anne; Kawas, C.; Brandt, Jason.

In: Neurology, Vol. 45, No. 1, 1995, p. 51-55.

Research output: Contribution to journalArticle

Rich, JB, Rasmusson, DX, Folstein, MF, Carson, KA, Kawas, C & Brandt, J 1995, 'Nonsteroidal anti-inflammatory drugs in alzheimer's disease', Neurology, vol. 45, no. 1, pp. 51-55.
Rich, J. B. ; Rasmusson, D. X. ; Folstein, Marshal F. ; Carson, Kathryn Anne ; Kawas, C. ; Brandt, Jason. / Nonsteroidal anti-inflammatory drugs in alzheimer's disease. In: Neurology. 1995 ; Vol. 45, No. 1. pp. 51-55.
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