Abstract
Objectives: To examine the relations between the use of nonaspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin and age-related change in multiple domains of cognitive function in community-dwelling individuals without dementia. Design: Longitudinal, with measures obtained on one to 18 occasions over up to 45 years. Setting: General community. Participants: A volunteer sample of up to 2,300 participants from the Baltimore Longitudinal Study of Aging free of diagnosed dementia. Measurements: At each visit, reported NSAID or aspirin use (yes/no) and tests of verbal and visual memory, attention, perceptuo-motor speed, confrontation naming, executive function, and mental status. Results: Mixed-effects regression models revealed that NSAID use was associated with less prospective decline on the Blessed Information-Memory- Concentration (I-M-C) Test, a mental status test weighted for memory and concentration (P
Original language | English (US) |
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Pages (from-to) | 38-43 |
Number of pages | 6 |
Journal | Journal of the American Geriatrics Society |
Volume | 58 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2010 |
Externally published | Yes |
Keywords
- Aspirin
- Cognitive function
- Neuropsychology
- Nsaids
ASJC Scopus subject areas
- Geriatrics and Gerontology