Nonrandom distribution of repeated DNA sequences with respect to supercoiled loops and the nuclear matrix

D. Small; B. Nelkin; B. Vogelstein

doi:10.1073/pnas.79.19.5911

Nonrandom distribution of repeated DNA sequences with respect to supercoiled loops and the nuclear matrix

D. Small, B. Nelkin, B. Vogelstein

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The DNA in a eukaryotic nucleus is arranged into a series of supercoiled loops that are anchored at their bases to the nuclear matrix. We have analyzed the DNA sequences that are closest to the matrix attachment points for their relative content of specific repeated sequences. Sequences were enriched (mouse satellite, human Alu family) or depleted (mouse EcoRI repeat, monkey α component), depending on the specific sequence and species examined. These results can be understood in terms of a nonrandom arrangement of DNA sequences with respect to nuclear DNA loops.

Original language	English (US)
Pages (from-to)	5911-5915
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	79
Issue number	19 I
DOIs	https://doi.org/10.1073/pnas.79.19.5911
State	Published - 1982

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