TY - JOUR
T1 - Nonrandom distribution of repeated DNA sequences with respect to supercoiled loops and the nuclear matrix
AU - Small, D.
AU - Nelkin, B.
AU - Vogelstein, B.
PY - 1982
Y1 - 1982
N2 - The DNA in a eukaryotic nucleus is arranged into a series of supercoiled loops that are anchored at their bases to the nuclear matrix. We have analyzed the DNA sequences that are closest to the matrix attachment points for their relative content of specific repeated sequences. Sequences were enriched (mouse satellite, human Alu family) or depleted (mouse EcoRI repeat, monkey α component), depending on the specific sequence and species examined. These results can be understood in terms of a nonrandom arrangement of DNA sequences with respect to nuclear DNA loops.
AB - The DNA in a eukaryotic nucleus is arranged into a series of supercoiled loops that are anchored at their bases to the nuclear matrix. We have analyzed the DNA sequences that are closest to the matrix attachment points for their relative content of specific repeated sequences. Sequences were enriched (mouse satellite, human Alu family) or depleted (mouse EcoRI repeat, monkey α component), depending on the specific sequence and species examined. These results can be understood in terms of a nonrandom arrangement of DNA sequences with respect to nuclear DNA loops.
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U2 - 10.1073/pnas.79.19.5911
DO - 10.1073/pnas.79.19.5911
M3 - Article
C2 - 6964395
AN - SCOPUS:0020441897
VL - 79
SP - 5911
EP - 5915
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 19 I
ER -