Nonrandom chromosome alterations in rhabdomyosarcoma

Jeffrey Trent, James Casper, Paul Meltzer, Floyd Thompson, Jørgen Fogh

Research output: Contribution to journalArticle

Abstract

Chromosome banding analysis was attempted on tumor cells from a total of six rhabdomyosarcomas. Results revealed a variety of chromosome alterations, including frequent structural rearrangement of chromosome #1 and the finding in one patient of multiple double minutes. The single chromosome most consistently involved in structural rearrangements was #3. Simple deletion or translocation of either the long or short arm of chromosome #3 was found in all rhabdomyosarcoma tumors examined in this report. Further, a review of the limited previous literature on rhabdomyosarcoma provided further support for the frequent alteration of chromosome #3 in this disease. Results from our study provide preliminary evidence that alterations of chromosome 3p14-21 may represent a site of nonrandom chromosome change in rhabdomyosarcoma.

Original languageEnglish (US)
Pages (from-to)189-197
Number of pages9
JournalCancer Genetics and Cytogenetics
Volume16
Issue number3
DOIs
StatePublished - Apr 1 1985
Externally publishedYes

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Rhabdomyosarcoma
Chromosomes
Chromosomes, Human, Pair 3
Chromosome Banding
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 1
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Trent, J., Casper, J., Meltzer, P., Thompson, F., & Fogh, J. (1985). Nonrandom chromosome alterations in rhabdomyosarcoma. Cancer Genetics and Cytogenetics, 16(3), 189-197. https://doi.org/10.1016/0165-4608(85)90045-7

Nonrandom chromosome alterations in rhabdomyosarcoma. / Trent, Jeffrey; Casper, James; Meltzer, Paul; Thompson, Floyd; Fogh, Jørgen.

In: Cancer Genetics and Cytogenetics, Vol. 16, No. 3, 01.04.1985, p. 189-197.

Research output: Contribution to journalArticle

Trent, J, Casper, J, Meltzer, P, Thompson, F & Fogh, J 1985, 'Nonrandom chromosome alterations in rhabdomyosarcoma', Cancer Genetics and Cytogenetics, vol. 16, no. 3, pp. 189-197. https://doi.org/10.1016/0165-4608(85)90045-7
Trent, Jeffrey ; Casper, James ; Meltzer, Paul ; Thompson, Floyd ; Fogh, Jørgen. / Nonrandom chromosome alterations in rhabdomyosarcoma. In: Cancer Genetics and Cytogenetics. 1985 ; Vol. 16, No. 3. pp. 189-197.
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